Evidence map›Paper›PMID 37894777›Full record

ArticleInternational journal of molecular sciences2023

Unravelling Novel

Anthony Frosio, Emanuele Micaglio, Ivan Polsinelli, Serena Calamaio, Dario Melgari, Rachele Prevostini, Andrea Ghiroldi, Anna Binda, Paola Carrera, Marco Villa and 9 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Selectivity Filter Mutation in NaJACC. Clinical electrophysiology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Anthony FrosioInstitute of Molecular and Translational Cardiology (IMTC), IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.ORCID 0000-0001-7628-989X
Emanuele MicaglioInstitute of Molecular and Translational Cardiology (IMTC), IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.ORCID 0000-0002-8298-7800
Ivan PolsinelliInstitute of Molecular and Translational Cardiology (IMTC), IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.ORCID 0000-0003-3664-0264
Serena CalamaioInstitute of Molecular and Translational Cardiology (IMTC), IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.ORCID 0000-0002-6616-1005
Dario MelgariInstitute of Molecular and Translational Cardiology (IMTC), IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.ORCID 0000-0002-0563-8041
Rachele PrevostiniInstitute of Molecular and Translational Cardiology (IMTC), IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.ORCID 0009-0005-8238-4443
Andrea GhiroldiInstitute of Molecular and Translational Cardiology (IMTC), IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.ORCID 0000-0002-2896-7390
Anna BindaSchool of Medicine and Surgery, University of Milano-Bicocca, Via Cadore, 48, 20900 Monza, Italy.
Paola CarreraLaboratory of Clinical Molecular Genetics and Cytogenetics, Unit of Genomics for Diagnosis of Human Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.ORCID 0000-0001-7376-2119
Marco VillaInstitute of Molecular and Translational Cardiology (IMTC), IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.ORCID 0000-0001-5300-1590
Flavio MastrocinqueArrhythmia and Electrophysiology Department, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.ORCID 0000-0003-0902-9136
Silvia PresiLaboratory of Clinical Molecular Genetics and Cytogenetics, Unit of Genomics for Diagnosis of Human Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.ORCID 0000-0002-7039-2228
Raffaele SalernoFaculty of Medicine and Surgery, Vita-Salute San Raffaele University, Via Olgettina, 58, 20132 Milan, Italy.
Antonio BoccellinoArrhythmia and Electrophysiology Department, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.
Luigi AnastasiaInstitute of Molecular and Translational Cardiology (IMTC), IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.
Giuseppe CiconteInstitute of Molecular and Translational Cardiology (IMTC), IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.
Stefano RicagnoInstitute of Molecular and Translational Cardiology (IMTC), IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.ORCID 0000-0001-6678-5873
Carlo PapponeInstitute of Molecular and Translational Cardiology (IMTC), IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.
Ilaria RivoltaInstitute of Molecular and Translational Cardiology (IMTC), IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.ORCID 0000-0002-7411-9069
IRCCS Policlinico San Donato · ITVita-Salute San Raffaele University · ITUniversity of Milan · ITUniversity of Milano-Bicocca · IT

Funding

Ricerca Corrente funding from the Italian Ministry of Health to IRCCS Policlinico San Donato, and by the University of Milano-Bicocca, 2016-CONT-0494 2016-CONT-0494
6 · The paper itself

Abstract

Brugada Syndrome (BrS) is a rare inherited cardiac arrhythmia causing potentially fatal ventricular tachycardia or fibrillation, mainly occurring during rest or sleep in young individuals without heart structural issues. It increases the risk of sudden cardiac death, and its characteristic feature is an abnormal ST segment elevation on the ECG. While BrS has diverse genetic origins, a subset of cases can be conducted to mutations in the

Indexed as

Brugada SyndromeArrhythmias, CardiacHumansMutationNAV1.5 Voltage-Gated Sodium ChannelNAV1.5 Voltage-Gated Sodium ChannelSCN5A protein, humanarrhythmiasautomated patch clampBrugada syndromemexiletineNav1.5SCN5Asodium channelsudden cardiac death

Identifiers

PMID37894777
PMCPMC10606416
OpenAlexW4387573709

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.