Evidence map›Paper›PMID 37894709›Full record

ArticleMolecules (Basel, Switzerland)2023

Synthesis, Computational, and Anticancer In Vitro Investigations of Aminobenzylnaphthols Derived from 2-Naphtol, Benzaldehydes, and α-Aminoacids via the Betti Reaction.

Mateusz Kciuk, Martyna Malinowska, Adrianna Gielecińska, Rajamanikandan Sundaraj, Somdutt Mujwar, Anna Zawisza, Renata Kontek

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mateusz KciukUniversity of Lodz, Faculty of Biology and Environmental Protection, Department of Molecular Biotechnology and Genetics, Banacha St. 12/16, 90-237 Lodz, Poland.ORCID 0000-0002-8616-3825
Martyna MalinowskaUniversity of Lodz, Department of Organic and Applied Chemistry, Tamka 12, 91-403 Lodz, Poland.ORCID 0000-0002-2590-5645
Adrianna GielecińskaUniversity of Lodz, Faculty of Biology and Environmental Protection, Department of Molecular Biotechnology and Genetics, Banacha St. 12/16, 90-237 Lodz, Poland.ORCID 0000-0001-9562-3582
Rajamanikandan SundarajCentre for Drug Discovery, Department of Biochemistry, Karpagam Academy of Higher Education, Coimbatore 641021, Tamil Nadu, India.
Somdutt MujwarChitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India.ORCID 0000-0003-4037-5475
Anna ZawiszaUniversity of Lodz, Department of Organic and Applied Chemistry, Tamka 12, 91-403 Lodz, Poland.ORCID 0000-0001-8801-8210
Renata KontekUniversity of Lodz, Faculty of Biology and Environmental Protection, Department of Molecular Biotechnology and Genetics, Banacha St. 12/16, 90-237 Lodz, Poland.ORCID 0000-0003-2859-9839

Funding

InterChemMed program WND-POWR.03.02.00-00-1029/16-01
6 · The paper itself

Abstract

Multicomponent reactions have emerged as an important approach for the synthesis of diverse and complicated chemical compounds. They have various advantages over two-component reactions, including the convenience of one-pot procedures and the ability to modify the structure of agents. Here, we employed in vitro and in silico studies to explore the anticancer potential of novel aminobenzylnaphthols derived from the Betti reaction (

Indexed as

Antineoplastic AgentsBenzaldehydesCarrier ProteinsCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHT29 CellsHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsBenzaldehydesCarrier ProteinsTRIM24 protein, humananticancerapoptosisBetti basescytotoxicitymolecular dockingmolecular dynamics

Identifiers

PMID37894709
PMCPMC10609152

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.