Evidence map›Paper›PMID 37894663›Full record

ArticleMolecules (Basel, Switzerland)2023

Two Birds with One Stone: A Novel Dithiomaleimide-Based GalNAc-siRNA Conjugate Enabling Good siRNA Delivery and Traceability.

Sudong Kong, Xiaoqing Gao, Qianhui Wang, Jianguo Lin, Ling Qiu, Minhao Xie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sudong KongSchool of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.
Xiaoqing GaoSchool of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.
Qianhui WangSchool of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.
Jianguo LinNHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China.ORCID 0000-0003-1018-9794
Ling QiuSchool of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.
Minhao XieSchool of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.

Funding

Major Scientific Research Project of Jiangsu Commission of Health ZD2022036Science Technology and Development Project of Wuxi Y20212013
6 · The paper itself

Abstract

For the first time, a novel dithiomaleimides (DTM) based tetra-antennary GalNAc conjugate was developed, which enable both efficient siRNA delivery and good traceability, without incorporating extra fluorophores. This conjugate can be readily constructed by three click-type reactions, that is, amidations, thiol-dibromomaleimide addition and copper catalyzed azide-alkyne cycloaddition (CuAAC). And it also has comparable siRNA delivery efficiency, with a GalNAc L96 standard to

Indexed as

Click ChemistryFluorescent DyesAlkynesAzidesCatalysisCopperCycloaddition ReactionRNA, Small InterferingAlkynesAzidesCopperFluorescent DyesRNA, Small Interferingclick chemistrydithiomaleimidesGalNAc-siRNA conjugatesiRNA delivery

Identifiers

PMID37894663
PMCPMC10609014

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.