Evidence map›Paper›PMID 37894498›Full record

ArticleMolecules (Basel, Switzerland)2023

L-Arginine Enhances Oral Keratinocyte Proliferation under High-Glucose Conditions via Upregulation of

Junhe Shi, Trevor R Leonardo, Chen Han, Hiba I Bangash, Dandan Chen, Harsh M Trivedi, Lin Chen

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Junhe ShiNMPA Key Laboratory for Clinical Research and Evaluation of Traditional Chinese Medicine, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Trevor R LeonardoDepartment of Periodontics, College of Dentistry, University of Illinois Chicago, Chicago, IL 60612, USA.ORCID 0000-0003-0619-8436
Chen HanDepartment of Periodontics, College of Dentistry, University of Illinois Chicago, Chicago, IL 60612, USA.ORCID 0000-0003-1662-6561
Hiba I BangashDepartment of Periodontics, College of Dentistry, University of Illinois Chicago, Chicago, IL 60612, USA.
Dandan ChenColgate-Palmolive Company, Piscataway, NJ 08854, USA.
Harsh M TrivediColgate-Palmolive Company, Piscataway, NJ 08854, USA.
Lin ChenDepartment of Periodontics, College of Dentistry, University of Illinois Chicago, Chicago, IL 60612, USA.ORCID 0000-0001-8530-2363
University of Illinois Chicago · USColgate-Palmolive (United States) · USChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

Colgate-Palmolive (United States) A-2018-653-OC
6 · The paper itself

Abstract

High glucose inhibits oral keratinocyte proliferation. Diabetes can lead to delayed oral wound healing and periodontal disease. L-Arginine, one of the most versatile amino acids, plays an important role in wound healing, organ maturation, and development. In this study, L-Arginine was found to enhance oral keratinocyte proliferation under high-glucose conditions. RNA sequencing analysis discovered a significant number of genes differentially upregulated following L-Arginine treatment under high-glucose conditions. Cytochrome P450 family 1 subfamily A member 1 (

Indexed as

Cytochrome P-450 CYP1A1S-Phase Kinase-Associated ProteinsArginineCell ProliferationGlucoseKeratinocytesUp-RegulationArginineCytochrome P-450 CYP1A1GlucoseS-Phase Kinase-Associated ProteinsCYP1A1high glucoseL-Arginineoral keratinocyteproliferationSKP2SRSF5

Identifiers

PMID37894498
PMCPMC10609441
OpenAlexW4387495321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.