Evidence map›Paper›PMID 37894377›Full record

ReviewCancers2023

The Evolving Role of Stereotactic Body Radiation Therapy for Head and Neck Cancer: Where Do We Stand?

Issa Mohamad, Irene Karam, Ahmed El-Sehemy, Ibrahim Abu-Gheida, Akram Al-Ibraheem, Hossam Al-Assaf, Mohammed Aldehaim, Majed Alghamdi, Ibrahim Alotain, May Ashour and 3 more

Registry-linked trialAbstract readReview
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07337161 (Stereotactic Post-operative Radiotherapy for Intraparotid Metastatic Cutaneous Squamous Cell Carcinoma), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07337161 narecruitingnot on this mapstarted 2025, after this paper: background citation

Stereotactic Post-operative Radiotherapy for Intraparotid Metastatic Cutaneous Squamous Cell Carcinoma

TypeinterventionalSponsorDavid PalmaRan2025 to 2035Enrolled90ConditionsCutaneous, Head and Neck Cancer Squamous Cell CarcinomaArmsSBRT, Standard Radiation
3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. PPARα Agonism Enhances Immune Response to Radiotherapy While Dietary Oleic Acid Results in Counteraction.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Issa MohamadDepartment of Radiation Oncology, King Hussein Cancer Center, Amman 11941, Jordan.ORCID 0000-0003-0153-9131
Irene KaramDepartment of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, ON M4N3M5, Canada.
Ahmed El-SehemyFaculty of Medicine, University of Toronto, Toronto, ON M5S1A1, Canada.
Ibrahim Abu-GheidaDepartment of Radiation Oncology, Burjeel Medical City, Abu Dhabi 7400, United Arab Emirates.
Akram Al-IbraheemDepartment of Nuclear Medicine, King Hussein Cancer Center, Amman 11941, Jordan.ORCID 0000-0002-0978-4716
Hossam Al-AssafDepartment of Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh 11525, Saudi Arabia.
Mohammed AldehaimDepartment of Radiation Oncology, King Faisal Specialist Hospital and Research Center Riyadh, Riyadh 11211, Saudi Arabia.
Majed AlghamdiRadiation Oncology, Princess Noorah Oncology Center, King Abdulaziz Medical City, Ministry of National Guard Health Affairs-Western Region, Jeddah 21556, Saudi Arabia.
Ibrahim AlotainDepartment of Radiation Oncology, King Fahad Specialist, Dammam 31444, Saudi Arabia.
May AshourDepartment of Radiation Oncology, National Cancer Institute, Cairo University, Cairo 11796, Egypt.
Ahmad BushehriDepartment of Radiation Oncology, Kuwait Cancer Control Center, Kuwait 42262, Kuwait.
Mostafa ElHaddadClinical Oncology Department, Kasr Al-Ainy Center of Clinical Oncology and Nuclear Medicine, Kasr Al-Ainy School of Medicine, Cairo University, Cairo 12613, Egypt.
Ali HosniRadiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON M5G2M9, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stereotactic body radiation therapy (SBRT) is a precise and conformal radiation therapy (RT) that aims to deliver a high dose of radiation to the tumor whilst sparing surrounding normal tissue, making it an attractive option for head and neck cancer (HNC) patients who are not suitable for the traditional long course of RT with comprehensive RT target volume. Definitive SBRT for HNC has been investigated in different settings, including early stage glottis cancer, and as an alternative to brachytherapy boost after external beam RT. It is also used as a primary treatment option for elderly or medically unfit patients. More recently, an SBRT combination with immunotherapy in the neoadjuvant setting for HNC showed promising results. Salvage or adjuvant SBRT for HNC can be used in appropriately selected cases. Future studies are warranted to determine the optimum dose and fractionation schedules in any of these indications.

Indexed as

head and neck cancerhypofractionationSBRT

Identifiers

PMID37894377
PMCPMC10605184

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.