Evidence map›Paper›PMID 37894325›Full record

ArticleCancers2023

AKT2 Loss Impairs BRAF-Mutant Melanoma Metastasis.

Siobhan K McRee, Abraham L Bayer, Jodie Pietruska, Philip N Tsichlis, Philip W Hinds

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. The role of SPRED1 mutation in melanoma.European journal of medical research · 2025
    Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Siobhan K McReeProgram in Genetics, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA.ORCID 0000-0002-1539-2946
Abraham L BayerProgram in Immunology, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA.ORCID 0000-0001-7534-6354
Jodie PietruskaDepartment of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA 02111, USA.
Philip N TsichlisDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210, USA.
Philip W HindsProgram in Genetics, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA.
Tufts University · USThe Ohio State University · US

Funding

Comparing the role of MyD88 and TRIF in T-cell effector function and the development of heart failureF30HL162200 · NHLBI · TUFTS UNIVERSITY BOSTON · PI Abraham Bayer · 2022 to 2026
$238k
A role for AKT2 in BRAFV600E melanoma initiation, progression, and response to therapyF31CA210312 · NCI · TUFTS UNIVERSITY BOSTON · PI MCREE, SIOBHAN K. · 2016 to 2017
$75k
NCI NIH HHS F31 CA210312NHLBI NIH HHS F30 HL162200
6 · The paper itself

Abstract

Despite recent advances in treatment, melanoma remains the deadliest form of skin cancer due to its highly metastatic nature. Melanomas harboring oncogenic BRAF

Indexed as

AKTcancermelanomametastasissignaling

Identifiers

PMID37894325
PMCPMC10605002
OpenAlexW4387569316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.