ReviewMicroorganisms2023
Antimicrobial Multidrug Resistance: Clinical Implications for Infection Management in Critically Ill Patients.
Review in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Genomic features of mecA-harboring Staphylococcus epidermidis infecting an illegally traded rufous-bellied thrush (T. rufiventris).Veterinary research communications · 2026Article
- Microbiome Profiling and Antimicrobial Efficacy of a Novel Silver-Nanoparticle Hydrogel Dressing Against Clinical Isolates From Paediatric Burn Wounds.MicrobiologyOpen · 2026Article
- Strategies to prevent cross-transmission of multidrug-resistant microorganisms in intensive care units: A narrative review.Journal of intensive medicine · 2026Review
- Microbiological Profile and Antimicrobial Resistance Patterns in an Intensive Care Unit: Emphasis on ESKAPE Pathogens.Antibiotics (Basel, Switzerland) · 2026Article
- Mobile Genetic Elements as Central Drivers of Antimicrobial Resistance: Molecular Mechanisms, Evolutionary Ecology, One Health Implications and Control Strategies.Antibiotics (Basel, Switzerland) · 2026Review
- Prediction of genetic relatedness ofAntimicrobial agents and chemotherapy · 2026Article
- Micro/nanorobotics for sepsis diagnosis and therapy: a frontier in precision medicine.Theranostics · 2026Review
- Incidence and risk factors of infections in lung cancer patients receiving immunotherapy combined with chemotherapy: a real-world retrospective study.American journal of cancer research · 2026Article
- Antimicrobial stewardship programs in sepsis treatment: principles, impact, and future directions.The Korean journal of internal medicine · 2026Review
- Machine learning-based prediction of mortality and multidrug-resistant infection risks in ICU patients with suspected infection: a prospective national multicenter cohort study.BMC infectious diseases · 2025Article
- Factors affecting hospital-acquired infections in hospitalized patients in iran: a qualitative study.BMC research notes · 2025Article
- Early Diagnostic Markers and Risk Stratification in Sepsis: Prognostic Value of Neutrophil-to-Lymphocyte Ratio, Platelets, and the Carmeli Score.Biomedicines · 2025Article
- Machine Learning Models to Establish the Risk of Being a Carrier of Multidrug-Resistant Bacteria upon Admission to the ICU.Antibiotics (Basel, Switzerland) · 2025Article
- Baicalin: Natural Sources, Extraction Techniques, and Therapeutic Applications Against Bacterial Infections.Molecules (Basel, Switzerland) · 2025Review
- Multi-target antibacterial Ru-based metallodrugs containing phenylsulfonyl indole derivatives: synthesis and their efficacy against Gram-positive and -negative bacteria.RSC advances · 2025Article
- Unveiling the impact: COVID-19's influence on bacterial resistance in the Kingdom of Bahrain.World journal of virology · 2025Article
- An AI-Based Clinical Decision Support System for Antibiotic Therapy in Sepsis (KINBIOTICS): Use Case Analysis.JMIR human factors · 2025Article
- Comparative performances of the Qvella FAST system and conventional methods for rapid identification and antibiotic susceptibility testing on monomicrobial positive blood cultures.Journal of clinical microbiology · 2025Article
- Article
- Efficacy of Antimicrobial Dry Fog in Improving the Environmental Microbial Burden in an Inpatient Ward.Antibiotics (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increasing incidence of antimicrobial resistance (AMR) worldwide represents a serious threat in the management of sepsis. Due to resistance to the most common antimicrobials prescribed, multidrug-resistant (MDR) pathogens have been associated with delays in adequate antimicrobial therapy leading to significant increases in mortality, along with prolonged hospital length of stay (LOS) and increases in healthcare costs. In response to MDR infections and the delay of microbiological results, broad-spectrum antibiotics are frequently used in empirical antimicrobial therapy. This can contribute to the overuse and misuse of antibiotics, further promoting the development of resistance. Multiple measures have been suggested to combat AMR. This review will focus on describing the epidemiology and trends concerning MDR pathogens. Additionally, it will explore the crucial aspects of identifying patients susceptible to MDR infections and optimizing antimicrobial drug dosing, which are both pivotal considerations in the fight against AMR. Expert commentary: The increasing AMR in ICUs worldwide makes the empirical antibiotic therapy challenging in septic patients. An AMR surveillance program together with improvements in MDR identification based on patient risk stratification and molecular rapid diagnostic tools may further help tailoring antimicrobial therapies and avoid unnecessary broad-spectrum antibiotics. Continuous infusions of antibiotics, therapeutic drug monitoring (TDM)-based dosing regimens and combination therapy may contribute to optimizing antimicrobial therapy and limiting the emergence of resistance.
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