Evidence map›Paper›PMID 37894145›Full record

ArticleMicroorganisms2023

Enzymatic Cleavage of Stx2a in the Gut and Identification of Pancreatic Elastase and Trypsin as Possible Main Cleavers.

Sára Kellnerová, Silke Huber, Mariam Massri, Verena Fleischer, Klemens Losso, Bettina Sarg, Leopold Kremser, Heribert Talasz, Xiaohua He, Elisa Varrone and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Sára KellnerováInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Silke HuberInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-7021-1845
Mariam MassriInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0003-0787-5451
Verena FleischerInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Klemens LossoInstitute of Analytical Chemistry and Radiochemistry, University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-8542-3082
Bettina SargProtein Core Facility, Institute of Medical Biochemistry, Center of Chemistry and Biomedicine, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Leopold KremserProtein Core Facility, Institute of Medical Biochemistry, Center of Chemistry and Biomedicine, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Heribert TalaszProtein Core Facility, Institute of Medical Biochemistry, Center of Chemistry and Biomedicine, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0003-4555-718X
Xiaohua HeWestern Regional Research Center, U.S. Department of Agriculture, Agricultural Research Service, Albany, CA 74710, USA.
Elisa VarroneDepartment of Medical and Surgical Sciences, School of Medicine, University of Bologna, 40126 Bologna, Italy.
Maurizio BrigottiDepartment of Medical and Surgical Sciences, School of Medicine, University of Bologna, 40126 Bologna, Italy.
Gianluigi ArdissinoCenter for HUS Prevention, Control and Management at Pediatric Nephrology, Dialysis and Transplant Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Dorothea Orth-HöllerInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0003-2904-5192
Reinhard WürznerInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0001-6804-442X
Innsbruck Medical University · ATUniversity of Bologna · ITAgricultural Research Service · USFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITUniversität Innsbruck · AT

Funding

European Union 860044FWF Austrian Science Fund W1253
6 · The paper itself

Abstract

Shiga toxins (Stxs), especially the Stx2a subtype, are the major virulence factors involved in enterohemorrhagic

Indexed as

chymotrypsin-like elastase 3B (CELA3B)EHEC-associated hemolytic uremic syndrome (eHUS)enterohemorrhagic Escherichia coli (EHEC)furinShiga toxin 2a (Stx2a)trypsin

Identifiers

PMID37894145
PMCPMC10609011
OpenAlexW4387343006

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.