Evidence map›Paper›PMID 37894115›Full record

ArticleMicroorganisms2023

Occurrence of Neonatal Necrotizing Enterocolitis in Premature Neonates and Gut Microbiota: A Case-Control Prospective Multicenter Study.

Julio Aires, Zehra Esra Ilhan, Lancelot Nicolas, Laurent Ferraris, Johanne Delannoy, Maxime Bredel, Anne Chauvire-Drouard, Frédéric Barbut, Jean-Christophe Rozé, Patricia Lepage and 2 more

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. [Research progress on the relationship between anemia and neonatal necrotizing enterocolitis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Julio AiresFaculté de Pharmacie de Paris, Université Paris Cité, INSERM, UMR-S 1139 (3PHM), 75006 Paris, France.ORCID 0000-0002-8090-4565
Zehra Esra IlhanMicalis Institute, INRA, AgroParisTech, University Paris-Saclay, 91190 Paris, France.
Lancelot NicolasFaculté de Pharmacie de Paris, Université Paris Cité, INSERM, UMR-S 1139 (3PHM), 75006 Paris, France.ORCID 0000-0001-7237-1239
Laurent FerrarisFaculté de Pharmacie de Paris, Université Paris Cité, INSERM, UMR-S 1139 (3PHM), 75006 Paris, France.
Johanne DelannoyFaculté de Pharmacie de Paris, Université Paris Cité, INSERM, UMR-S 1139 (3PHM), 75006 Paris, France.
Maxime BredelMicalis Institute, INRA, AgroParisTech, University Paris-Saclay, 91190 Paris, France.
Anne Chauvire-DrouardCentre d'Investigation Clinique CIC 1413, INSERM, CHU de Nantes, 44093 Nantes, France.
Frédéric BarbutFaculté de Pharmacie de Paris, Université Paris Cité, INSERM, UMR-S 1139 (3PHM), 75006 Paris, France.ORCID 0000-0002-4165-0670
Jean-Christophe RozéDepartment of Neonatal Medicine, University Hospital of Nantes, 44093 Nantes, France.ORCID 0000-0003-3367-512X
Patricia LepageMicalis Institute, INRA, AgroParisTech, University Paris-Saclay, 91190 Paris, France.ORCID 0000-0002-9501-6771
Marie-José ButelFaculté de Pharmacie de Paris, Université Paris Cité, INSERM, UMR-S 1139 (3PHM), 75006 Paris, France.
ClosNEC Study Group
Inserm · FRAgroParisTech · FRCentre Hospitalier Universitaire de Nantes · FR

Funding

Agence Nationale de la Recherche ANR-13-PRTS-0018
6 · The paper itself

Abstract

backgroundNecrotizing enterocolitis (NEC) is still one of the leading causes of neonatal death. The present study reports the data from a French case-control prospective multicenter study.

methodsA total of 146 preterm neonates (PNs) with or without NEC were included. Bacterial 16S rRNA gene sequencing was performed on stool samples (n = 103). Specific culture media were used to isolate

resultsThe gut microbiota of PNs was dominated by Firmicutes and Proteobacteria, and five enterotypes were identified. The microbiota composition was similar between NEC cases and PN controls. However, differences were observed in the relative abundance of

conclusionsAt disease onset, our data support a microbiota dysbiosis between NEC and control infants at the genus level. In addition, it provides valuable information on bacterial antimicrobial susceptibility.

Indexed as

antimicrobial susceptibilityClostridium butyricumClostridium neonatalegut microbiotamulticenter studyNECnecrotizing enterocolitisUPECuropathogenic Escherichia coli

Identifiers

PMID37894115
PMCPMC10609581
OpenAlexW4387230419

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.