Evidence map›Paper›PMID 37893865›Full record

ArticleHealthcare (Basel, Switzerland)2023

Impact of COVID-19 Infection on Health-Related Quality of Life, Work Productivity and Activity Impairment by Symptom-Based Long COVID Status and Age in the US.

Manuela Di Fusco, Joseph C Cappelleri, Laura Anatale-Tardiff, Henriette Coetzer, Alon Yehoshua, Mary B Alvarez, Kristen E Allen, Thomas M Porter, Laura Puzniak, Ashley S Cha-Silva and 2 more

Abstract read
In one paragraph

Article in Healthcare (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. The EQ-5D-5L and Minimal Important Change in Long COVID.Advances in rehabilitation science and practice
    Article
  10. Risk factors for post-COVID-19 condition: A case-control study in municipalities of Paraíba and Rio de Janeiro, Brazil.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Manuela Di FuscoPfizer Inc., New York, NY 10001, USA.ORCID 0000-0003-0079-7331
Joseph C CappelleriPfizer Inc., New York, NY 10001, USA.
Laura Anatale-TardiffCVS Health, Woonsocket, RI 02895, USA.
Henriette CoetzerCVS Health, Woonsocket, RI 02895, USA.ORCID 0009-0009-7093-9279
Alon YehoshuaPfizer Inc., New York, NY 10001, USA.
Mary B AlvarezPfizer Inc., New York, NY 10001, USA.
Kristen E AllenPfizer Inc., New York, NY 10001, USA.
Thomas M PorterPfizer Inc., New York, NY 10001, USA.ORCID 0009-0005-5089-2873
Laura PuzniakPfizer Inc., New York, NY 10001, USA.
Ashley S Cha-SilvaPfizer Inc., New York, NY 10001, USA.ORCID 0000-0002-8484-6251
Santiago M C LopezPfizer Inc., New York, NY 10001, USA.
Xiaowu SunCVS Health, Woonsocket, RI 02895, USA.ORCID 0000-0002-7960-4207

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 infection adversely impacts patients' wellbeing and daily lives. This survey-based study examined differences in patient-reported COVID-19 symptoms, Health-Related Quality of Life (HRQoL) and Work Productivity and Activity Impairment (WPAI) among groups of patients defined based on age and symptom-based long COVID status. Symptomatic, COVID-19-positive US outpatients were recruited from 31 January-30 April 2022. Outcomes were collected via validated instruments at pre-COVID, Day 3, Week 1, Week 4, Month 3 and Month 6 following infection, with changes assessed from pre-COVID and between groups, adjusting for covariates. EQ-5D-5L HRQoL and WPAI scores declined in all groups, especially during the first week. Long COVID patients reported significantly higher symptoms burden and larger drops in HRQoL and WPAI scores than patients without long COVID. Their HRQoL and WPAI scores did not return to levels comparable to pre-COVID through Month 6, except for absenteeism. Patients without long COVID generally recovered between Week 4 and Month 3. Older (>50) and younger adults generally reported comparable symptoms burden and drops in HRQoL and WPAI scores. During the first week of infection, COVID-19-related health issues caused loss of 14 to 26 work hours across the groups. These data further knowledge regarding the differential impacts of COVID-19 on clinically relevant patient groups.

Indexed as

COVID-19COVID-19 symptomseconomichumanisticlong COVIDquality of lifeSARS-CoV-2

Identifiers

PMID37893865
PMCPMC10606451

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.