Evidence map›Paper›PMID 37893677›Full record

ArticleFoods (Basel, Switzerland)2023

Sulforaphane Bioavailability in Healthy Subjects Fed a Single Serving of Fresh Broccoli Microgreens.

John A Bouranis, Carmen P Wong, Laura M Beaver, Sandra L Uesugi, Ethan M Papenhausen, Jaewoo Choi, Edward W Davis, Adilson Nunes Da Silva, Newton Kalengamaliro, Rekha Chaudhary and 5 more

Open access · goldAbstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

John A BouranisLinus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.
Carmen P WongLinus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.
Laura M BeaverLinus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.
Sandra L UesugiLinus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.
Ethan M PapenhausenLinus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.
Jaewoo ChoiLinus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.
Edward W DavisCenter for Quantitative Life Sciences, Oregon State University, Corvallis, OR 97331, USA.ORCID 0000-0003-1229-4272
Adilson Nunes Da Silva80 Acres Farms, Hamilton, OH 45011, USA.
Newton Kalengamaliro80 Acres Farms, Hamilton, OH 45011, USA.
Rekha ChaudharyDepartment of Medical Oncology, University of Cincinnati, Cincinnati, OH 45221, USA.
Jordan KharofaDepartment of Radiation Oncology, University of Cincinnati, Cincinnati, OH 45221, USA.
Vinita TakiarDepartment of Radiation Oncology, University of Cincinnati, Cincinnati, OH 45221, USA.ORCID 0000-0002-2499-3516
Thomas J HerzogDepartment of OB/GYN, Division of Gynecologic Oncology, University of Cincinnati, Cincinnati, OH 45221, USA.ORCID 0000-0002-4584-8908
William BarrettDepartment of Radiation Oncology, University of Cincinnati, Cincinnati, OH 45221, USA.
Emily HoLinus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.ORCID 0000-0002-7687-2820
Oregon State University · USUniversity of Cincinnati · US

Funding

Zebrafish Biomedical Research Facility CoreP30ES030287 · NIEHS · OREGON STATE UNIVERSITY · PI Jamie DeWitt · 2020 to 2026
$9.8M
Triple Quadrupole/Linear Ion Trap LC-MS/MS for LPIS10RR027878 · NCRR · OREGON STATE UNIVERSITY · PI STEVENS, JAN FREDERIK · 2010 to 2010
$484k
NCRR NIH HHS S10 RR027878NIEHS NIH HHS P30 ES030287NIH HHS P30ES030287NIH HHS S10RR027878
6 · The paper itself

Abstract

Cruciferous vegetable consumption is associated with numerous health benefits attributed to the phytochemical sulforaphane (SFN) that exerts antioxidant and chemopreventive properties, among other bioactive compounds. Broccoli sprouts, rich in SFN precursor glucoraphanin (GRN), have been investigated in numerous clinical trials. Broccoli microgreens are similarly rich in GRN but have remained largely unexplored. The goal of this study was to examine SFN bioavailability and the microbiome profile in subjects fed a single serving of fresh broccoli microgreens. Eleven subjects participated in a broccoli microgreens feeding study. Broccoli microgreens GRN and SFN contents and stability were measured. Urine and stool SFN metabolite profiles and microbiome composition were examined. Broccoli microgreens had similar GRN content to values previously reported for broccoli sprouts, which was stable over time. Urine SFN metabolite profiles in broccoli microgreens-fed subjects were similar to those reported previously in broccoli sprouts-fed subjects, including the detection of SFN-nitriles. We also reported the detection of SFN metabolites in stool samples for the first time. A single serving of broccoli microgreens did not significantly alter microbiome composition. We showed in this study that broccoli microgreens are a significant source of SFN. Our work provides the foundation for future studies to establish the health benefits of broccoli microgreens consumption.

Indexed as

broccoli microgreenscruciferous vegetablesmicrobiomesulforaphanesulforaphane-nitrile

Identifiers

PMID37893677
PMCPMC10606698
OpenAlexW4387653439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.