Evidence map›Paper›PMID 37893147›Full record

ArticleBiomedicines2023

Prognostic Significance of Amino Acid and Biogenic Amines Profiling in Chronic Kidney Disease.

Guillermo Gervasini, Zoraida Verde, Luz M González, Celia Chicharro, Laura González-Rodríguez, Ana Fernández-Araque, Sonia Mota-Zamorano, Bárbara Cancho, Alberto Pérez-Hernández, Virginio García-López and 2 more

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Guillermo GervasiniDepartment of Medical and Surgical Therapeutics, Medical School, University of Extremadura, 06006 Badajoz, Spain.ORCID 0000-0002-0524-9767
Zoraida VerdeDepartment of Biochemistry, Molecular Biology and Physiology, Universidad de Valladolid, 42005 Soria, Spain.ORCID 0000-0002-9260-7672
Luz M GonzálezDepartment of Medical and Surgical Therapeutics, Medical School, University of Extremadura, 06006 Badajoz, Spain.
Celia ChicharroResearch Group Centro de Estudios Gregorio Marañón, Fundación Ortega-Marañón, 28010 Madrid, Spain.
Laura González-RodríguezDepartment of Medical and Surgical Therapeutics, Medical School, University of Extremadura, 06006 Badajoz, Spain.
Ana Fernández-AraqueGIR-Pharmacogenetics, Cancer Genetics, Genetic Polymorphisms and Pharmacoepidemiology, University of Valladolid, 47005 Valladolid, Spain.ORCID 0000-0002-5324-1014
Sonia Mota-ZamoranoDepartment of Medical and Surgical Therapeutics, Medical School, University of Extremadura, 06006 Badajoz, Spain.
Bárbara CanchoService of Nephrology, Badajoz University Hospital, 06006 Badajoz, Spain.
Alberto Pérez-HernándezDepartment of Clinical Biochemistry, Hospital Santa Bárbara, 42005 Soria, Spain.
Virginio García-LópezDepartment of Medical and Surgical Therapeutics, Medical School, University of Extremadura, 06006 Badajoz, Spain.ORCID 0000-0003-1489-7296
Fernando BandrésResearch Group Centro de Estudios Gregorio Marañón, Fundación Ortega-Marañón, 28010 Madrid, Spain.
Nicolás R RoblesRICORS2040 Renal Research Network, 28029 Madrid, Spain.ORCID 0000-0003-4984-6691
Spanish Clinical Research Network · ESUniversidad de Extremadura · ESUniversidad Complutense de Madrid · ESUniversidad de Valladolid · ESCentro de Implantología Cirugía Oral y Maxilofacial · ES

Funding

Instituto de Salud Carlos III PI22/00181Instituto de Salud Carlos III RD21/0005/0031Junta de Extremadura GR21026
6 · The paper itself

Abstract

There is a pressing need for more precise biomarkers of chronic kidney disease (CKD). Plasma samples from 820 subjects [231 with CKD, 325 with end-stage kidney disease (ESKD) and 264 controls] were analyzed by liquid chromatography with tandem mass spectrometry (LC-MS/MS) to determine a metabolic profile of 28 amino acids (AAs) and biogenic amines to test their value as markers of CKD risk and progression. The kynurenine/tryptophan ratio showed the strongest correlation with estimated glomerular filtration rate values (coefficient = -0.731,

Indexed as

amino acidschronic kidney diseaseend-stage kidney diseasemetabolites

Identifiers

PMID37893147
PMCPMC10604890
OpenAlexW4387617237

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.