Evidence map›Paper›PMID 37893143›Full record

ArticleBiomedicines2023

Periodontal Disease, Local and Systemic Inflammation in Puerto Ricans with Type 2 Diabetes Mellitus.

Oelisoa M Andriankaja, Reuben Adatorwovor, Alpdogan Kantarci, Hatice Hasturk, Luciana Shaddox, Michael A Levine

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Animal cells and systems · 2025
    Article
  3. Machine Learning-Based Classification of Diabetes: Model Accuracy, Feature Importance, and Clinical Implications.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Oelisoa M AndriankajaCenter for Oral Health Research (COHR), University of Kentucky College of Dentistry, Lexington, KY 40536, USA.
Reuben AdatorwovorCollege of Public Health, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0002-0503-3173
Alpdogan KantarciThe Forsyth Institute, Cambridge, MA 02142, USA.
Hatice HasturkCenter for Clinical and Translational Research, The Forsyth Institute, Cambridge, MA 02142, USA.
Luciana ShaddoxCenter for Oral Health Research (COHR), University of Kentucky College of Dentistry, Lexington, KY 40536, USA.
Michael A LevineCenter for Bone Health, Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0003-0036-7809
University of Kentucky · USChildren's Hospital of Philadelphia · US

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
MECHANISMS OF PERIODONTAL DESTRUCTIONR01DE011254 · NIDCR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GRAVES, DANA T · 1995 to 2002
$882k
Study of Pathways in the Link Between Type 2 Diabetes and PeriodontitisK23DE025313 · NIDCR · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI ANDRIANKAJA, OELISOA M · 2016 to 2020
$809k
NCATS NIH HHS UL1 TR001998NCATS NIH HHS UL1TR001998NIDCR NIH HHS K23 DE025313NIDCR NIH HHS R01 DE011254
6 · The paper itself

Abstract

Periodontal disease (PD) is prevalent in type 2 diabetic condition (T2DM).

objectivesWe assessed the associations between serum or gingival crevicular fluid (GCF) endothelial and inflammatory mediators and chronic PD among T2DM Hispanic adults.

methodsWe enrolled 248 Puerto Rican residents with T2DM aged 40-65 years. The exposures included serum inflammatory mediators (IL-1b, IL-6, IL-10, and TNF-α), endothelial adhesion molecules, RANKL levels, and the GCF content of these analytes from a subset of 158 samples. The outcomes included the percent of sites with a probing pocket depth (PPD) ≥ 4 mm and clinical attachment loss ≥ 4 mm. Adjusted logistic regression models were fit to the categorized outcomes.

resultsIncreased serum IL-10 (Adj. OR: 1.10,

conclusionsOur findings suggested that oral and systemic endothelial and inflammatory mediators are associated with periodontal clinical parameters among Hispanic adults with T2DM.

Indexed as

cytokinesdiabetes mellitusendotheliuminflammationperiodontitis

Identifiers

PMID37893143
PMCPMC10604368
OpenAlexW4387568439

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.