Evidence map›Paper›PMID 37893093›Full record

ArticleBiomedicines2023

A Mouse Model for the Rapid and Binomial Assessment of Putative WNT/β-Catenin Signalling Inhibitors.

Janson Tse, Ryan O'Keefe, Angela Rigopolous, Annalisa L E Carli, Jo Waaler, Stefan Krauss, Matthias Ernst, Michael Buchert

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Janson TseCancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia.
Ryan O'KeefeCancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia.ORCID 0000-0002-8527-2165
Angela RigopolousSchool of Cancer Medicine, La Trobe University, Bundoora, VIC 3086, Australia.
Annalisa L E CarliCancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia.ORCID 0000-0003-0312-1097
Jo WaalerDepartment of Immunology and Transfusion Medicine, Oslo University Hospital, Rikshospitalet, 0424 Oslo, Norway.
Stefan KraussDepartment of Immunology and Transfusion Medicine, Oslo University Hospital, Rikshospitalet, 0424 Oslo, Norway.
Matthias ErnstCancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia.ORCID 0000-0002-6399-1177
Michael BuchertCancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia.ORCID 0000-0003-2672-0148
La Trobe University · AUOslo University Hospital · NOOlivia Newton-John Cancer Wellness & Research Centre · AU

Funding

National Health and Medical Research Council 1079257National Health and Medical Research Council 1092788National Health and Medical Research Council 1143020National Health and Medical Research Council 1173814National Health and Medical Research Council 2020316South-Eastern Norway Regional Health Authority 2019090South-Eastern Norway Regional Health Authority 2021035The Research Council of Norway 174938/O30
6 · The paper itself

Abstract

Specific signalling thresholds of the WNT/β-catenin pathway affect embryogenesis and tissue homeostasis in the adult, with mutations in this pathway frequently occurring in cancer. Excessive WNT/β-catenin activity inhibits murine anterior development associated with embryonic lethality and accounts for the driver event in 80% of human colorectal cancers. Uncontrolled WNT/β-catenin signalling arises primarily from impairment mutation in the tumour suppressor gene

Indexed as

APCin vivo assaypyrvinium pamoatetankyrase inhibitorWNT inhibitorsWNT/β-catenin signalling

Identifiers

PMID37893093
PMCPMC10604108
OpenAlexW4387421250

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.