Evidence map›Paper›PMID 37893006›Full record

ArticleBiomedicines2023

Beyond the Rhythm: In Silico Identification of Key Genes and Therapeutic Targets in Atrial Fibrillation.

Natalia Atzemian, Nikolas Dovrolis, Georgia Ragia, Konstantina Portokallidou, George Kolios, Vangelis G Manolopoulos

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Natalia AtzemianLaboratory of Pharmacology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0009-0005-7793-7082
Nikolas DovrolisLaboratory of Pharmacology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0003-3832-9939
Georgia RagiaLaboratory of Pharmacology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Konstantina PortokallidouLaboratory of Pharmacology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
George KoliosLaboratory of Pharmacology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0002-2066-4782
Vangelis G ManolopoulosLaboratory of Pharmacology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0003-0849-5469
Democritus University of Thrace · GR

Funding

Financial support for project IMPReS (MIS 5047189) was provided by the Program "Competi-tiveness, Entrepreneurship and Innovation" (NSRF 2014-2020) co-financed by Greece and the European Union (European Regional Development Fund). MIS 5047189
6 · The paper itself

Abstract

Atrial fibrillation (AF) is a prevalent cardiac arrhythmia worldwide and is characterized by a high risk of thromboembolism, ischemic stroke, and fatality. The precise molecular mechanisms of AF pathogenesis remain unclear. The purpose of this study was to use bioinformatics tools to identify novel key genes in AF, provide deeper insights into the molecular pathogenesis of AF, and uncover potential therapeutic targets. Four publicly available raw RNA-Seq datasets obtained through the ENA Browser, as well as proteomic analysis results, both derived from atrial tissues, were used in this analysis. Differential gene expression analysis was performed and cross-validated with proteomics results to identify common genes/proteins between them. A functional enrichment pathway analysis was performed. Cross-validation analysis revealed five differentially expressed genes, namely

Indexed as

atrial fibrillationatrial remodelingbioinformaticsfibrosisproteomicstranscriptomics

Identifiers

PMID37893006
PMCPMC10604372
OpenAlexW4387055218

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.