Evidence map›Paper›PMID 37892972›Full record

ArticleBiomedicines2023

Oct4 and Hypoxia Dual-Regulated Oncolytic Adenovirus Armed with shRNA-Targeting Dendritic Cell Immunoreceptor Exerts Potent Antitumor Activity against Bladder Cancer.

Che-Yuan Hu, Chi-Feng Hung, Pi-Che Chen, Jia-Yu Hsu, Chung-Teng Wang, Ming-Derg Lai, Yuh-Shyan Tsai, Ai-Li Shiau, Gia-Shing Shieh, Chao-Liang Wu

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Che-Yuan HuDepartment of Urology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.ORCID 0000-0001-5151-4552
Chi-Feng HungDepartment of Urology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City 60002, Taiwan.
Pi-Che ChenDepartment of Urology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City 60002, Taiwan.
Jia-Yu HsuDepartment of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Chung-Teng WangDepartment of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Ming-Derg LaiDepartment of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Yuh-Shyan TsaiDepartment of Urology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.ORCID 0000-0001-7613-3772
Ai-Li ShiauDepartment of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.ORCID 0000-0003-2449-8547
Gia-Shing ShiehDepartment of Urology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Chao-Liang WuDepartment of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.ORCID 0000-0001-7821-9406
National Cheng Kung University · TWChia-Yi Christian Hospital · TWChest Hospital, Ministry of Health and Welfare · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunotherapy has emerged as a promising modality for cancer treatment. Dendritic cell immunoreceptor (DCIR), a C-type lectin receptor, is expressed mainly by dendritic cells (DCs) and mediates inhibitory intracellular signaling. Inhibition of DCIR activation may enhance antitumor activity. DCIR is encoded by

Indexed as

bladder cancerdendritic celldendritic cell immunoreceptorhypoxiaimmunotherapyOct4oncolytic adenovirus

Identifiers

PMID37892972
PMCPMC10604824
OpenAlexW4386960078

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.