Evidence map›Paper›PMID 37892933›Full record

ArticleBioengineering (Basel, Switzerland)2023

Mesoporous Bioactive Glass-Incorporated Injectable Strontium-Containing Calcium Phosphate Cement Enhanced Osteoconductivity in a Critical-Sized Metaphyseal Defect in Osteoporotic Rats.

Seemun Ray, Ulrich Thormann, Inga Kramer, Ursula Sommer, Matthäus Budak, Matthias Schumacher, Anne Bernhardt, Anja Lode, Christine Kern, Marcus Rohnke and 4 more

Abstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Seemun RayLaboratory of Experimental Trauma Surgery, Justus Liebig University, 35390 Giessen, Germany.
Ulrich ThormannLaboratory of Experimental Trauma Surgery, Justus Liebig University, 35390 Giessen, Germany.ORCID 0000-0002-8935-4731
Inga KramerLaboratory of Experimental Trauma Surgery, Justus Liebig University, 35390 Giessen, Germany.
Ursula SommerLaboratory of Experimental Trauma Surgery, Justus Liebig University, 35390 Giessen, Germany.
Matthäus BudakLaboratory of Experimental Trauma Surgery, Justus Liebig University, 35390 Giessen, Germany.
Matthias SchumacherCentre for Translational Bone, Joint, and Soft Tissue Research, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
Anne BernhardtCentre for Translational Bone, Joint, and Soft Tissue Research, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.ORCID 0000-0002-1903-1929
Anja LodeCentre for Translational Bone, Joint, and Soft Tissue Research, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.ORCID 0000-0001-7704-6435
Christine KernInstitute of Physical Chemistry, Justus Liebig University Giessen, 35392 Giessen, Germany.
Marcus RohnkeInstitute of Physical Chemistry, Justus Liebig University Giessen, 35392 Giessen, Germany.ORCID 0000-0002-8867-950X
Christian HeissLaboratory of Experimental Trauma Surgery, Justus Liebig University, 35390 Giessen, Germany.
Katrin S LipsLaboratory of Experimental Trauma Surgery, Justus Liebig University, 35390 Giessen, Germany.ORCID 0000-0003-3320-7545
Michael GelinskyCentre for Translational Bone, Joint, and Soft Tissue Research, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.ORCID 0000-0001-9075-5121
Volker AltLaboratory of Experimental Trauma Surgery, Justus Liebig University, 35390 Giessen, Germany.ORCID 0000-0003-0208-4650

Funding

Deutsche Forschungsgemeinschaft SFB/TR 79
6 · The paper itself

Abstract

In this study, the in vitro and in vivo bone formation behavior of mesoporous bioactive glass (MBG) particles incorporated in a pasty strontium-containing calcium phosphate bone cement (pS100G10) was studied in a metaphyseal fracture-defect model in ovariectomized rats and compared to a plain pasty strontium-containing calcium phosphate bone cement (pS100) and control (empty defect) group, respectively. In vitro testing showed good cytocompatibility on human preosteoblasts and ongoing dissolution of the MBG component. Neither the released strontium nor the BMG particles from the pS100G10 had a negative influence on cell viability. Forty-five female Sprague-Dawley rats were randomly assigned to three different treatment groups: (1) pS100 (

Indexed as

biomaterialfracture defectmesoporous bioactive glassosteoporosisstrontium

Identifiers

PMID37892933
PMCPMC10604136

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.