ArticleJournal of clinical medicine2023
Syringomyelia Is Associated with a Reduction in Spinal Canal Compliance, Venous Outflow Dilatation and Glymphatic Fluid Obstruction.
Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- A Lumped Parameter Modelling Study of Leukoaraiosis Suggests Its Vascular Pathophysiology May Be Similar to Normal-Pressure Hydrocephalus.Brain sciences · 2025Article
- Adult-Onset Syringomyelia in Dandy-Walker Malformation Patients: Clinical Insights and Literature Review.Brain sciences · 2025Article
- Fourth ventricular stenting in foramen magnum decompression for type 1 Chiari malformations with syringomyelia.Surgical neurology international · 2025Article
- A Lumped Parameter Model Suggests That Infusion Studies Overestimate the Cerebrospinal Fluid Outflow Resistance in Normal Pressure Hydrocephalus.Brain sciences · 2024Article
- A lumped parameter modelling study of cerebral autoregulation in normal pressure hydrocephalus suggests the brain chooses to be ischemic.Scientific reports · 2024Article
- A perspective on the evidence for glymphatic obstruction in spaceflight associated neuro-ocular syndrome and fatigue.NPJ microgravity · 2024Review
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
The cause of the cystic dilatation of the cord found in syringomyelia has been a source of conjecture for a considerable time. Recent studies have shown that there is a reduction in craniospinal compliance in both childhood hydrocephalus and multiple sclerosis which leads to venous outflow dilatation. Both diseases are associated with glymphatic outflow obstruction. Venous dilatation will narrow the perivenous glymphatic outflow pathway and lead to an increase in glymphatic outflow resistance. Syringomyelia has been shown to be associated with reduced spinal canal compliance. This paper discusses the possibility that venous dilatation and obstructed glymphatic outflow within the cord may be behind the cystic dilatation found within syringomyelia.
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Registered trials
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