ReviewJournal of clinical medicine2023
Knee Cartilage Lesion Management-Current Trends in Clinical Practice.
Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The use of autologous chondrocyte transplantation for the treatment of osteoarthritis: a systematic review of clinical trials.Cell and tissue banking · 2024Pooled it
- MSC-Hydrogel Composite Systems for Knee Cartilage Repair and Osteoarthritis: A Systematic Review.Gels (Basel, Switzerland) · 2026Review
- Long-term outcomes of arthroscopic single-anchor fixation versus microfracture for osteochondral fractures of the knee weight-bearing area in adolescents and young adults.Archives of orthopaedic and trauma surgery · 2026Article
- Conditional Survivorship of Osteochondral Allograft Transplantation in the Knee.Orthopaedic journal of sports medicine · 2026Article
- Medial meniscus posterior root tear with concomitant focal cartilage lesion may be successfully treated with pullout repair combined with additional bone marrow stimulation.Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology · 2026Article
- Surgical treatment of isolated cartilage lesions during anterior cruciate ligament reconstruction was associated with greater lesion stability but similar 2-year clinical outcomes: A registry-based matched-pair second-look study.Journal of experimental orthopaedics · 2026Article
- Surgical Technique for Treating Focal Osteochondral Knee Lesions Using an Aragonite-Based Biphasic Scaffold.Arthroscopy techniques · 2026Article
- Femoral Osteochondritis Dissecans and Tibial Osteochondral Defect in an Adult Revealed by Bone SPECT/CT.Diagnostics (Basel, Switzerland) · 2026Article
- Mid-Term Clinical Outcomes of Pullout Repair Combined with Osteochondral Autograft Transplantation for Medial Meniscus Posterior Root Tears with Focal Cartilage Defects: A Treatment-Stratified Cohort Study.Bioengineering (Basel, Switzerland) · 2026Article
- Innovative Technologies for Articular Cartilage Repair: Research, Development, and Clinical Translation-A Narrative Review.Journal of functional biomaterials · 2026Review
- Patient and Chondral Defect-Specific Characteristics an Associated Matrix-Induced Autologous Chondrocyte Implantation Conversion Rates Following Biopsy.Orthopaedic journal of sports medicine · 2026Article
- Intelligent treatment strategies for knee cartilage injury repair.Frontiers in surgery · 2026Review
- COArthroscopy techniques · 2025Article
- Cell-derived extracellular matrix scaffolds augmented with bone marrow aspirate concentrate promote cartilage regeneration.Materials today. Bio · 2025Article
- The Impact of Aging on Meniscal Tears and Chondral Lesions in Men: Insights from First-Time Arthroscopic Knee Evaluation.Life (Basel, Switzerland) · 2025Article
- Bioinformatic prediction of key genes involved in pro-chondrogenic effect of fragmentated cartilage transplantation.Scientific reports · 2025Article
- AMIC achieves sustained clinical improvement in isolated patellar cartilage defects over 5 years, correlating with MRI.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Article
- Treatment of an Osteochondral Defect of the Trochlea Using Matrix-Induced Autologous Chondrocyte Implantation and Proximal Tibia Autologous Bone Grafting.Arthroscopy techniques · 2025Article
- Mesenchymal stem cells improve osteoarthritis by secreting superoxide dismutase to regulate oxidative stress response.BMC musculoskeletal disorders · 2025Article
- Minimally Invasive Unicompartmental Articular Resurfacing.Arthroscopy techniques · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many patients, particularly those aged above 40, experience knee joint pain, which hampers both sports activities and daily living. Treating isolated chondral and osteochondral defects in the knee poses a significant clinical challenge, particularly in younger patients who are not typically recommended partial or total knee arthroplasty as alternatives. Several surgical approaches have been developed to address focal cartilage defects. The treatment strategies are characterized as palliation (e.g., chondroplasty and debridement), repair (e.g., drilling and microfracture), or restoration (e.g., autologous chondrocyte implantation, osteochondral autograft, and osteochondral allograft). This review offers an overview of the commonly employed clinical methods for treating articular cartilage defects, with a specific focus on the clinical trials conducted in the last decade. Our study reveals that, currently, no single technology fully meets the essential requirements for effective cartilage healing while remaining easily applicable during surgical procedures. Nevertheless, numerous methods are available, and the choice of treatment should consider factors such as the location and size of the cartilage lesion, patient preferences, and whether it is chondral or osteochondral in nature. Promising directions for the future include tissue engineering, stem cell therapies, and the development of pre-formed scaffolds from hyaline cartilage, offering hope for improved outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.