ArticleJournal of clinical medicine2023
Increasing Soluble P-Selectin Levels Predict Higher Peripheral Atherosclerotic Plaque Progression.
Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Inflammatory and Cardiovascular Responses to Active and Passive Acute Psychological Stress.Biopsychosocial science and medicineTrial
- Atherosclerosis Progression Evaluation in Coronary Arteries by Computed Tomography Compared to Peripheral Vessels Using 3D Ultrasonography.Journal of clinical medicine · 2026Article
- Mitochondrial-Endothelial Crosstalk in Cardiometabolic Disease: Mechanisms and Translational Opportunities in the Multi-omics Era.Reviews in cardiovascular medicine · 2026Review
- Profiling endothelial function, oxidative stress and inflammatory biomarkers in individuals with various cardiovascular risk factors: the African-PREDICT study.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Mechanism of Neutrophil p90RSK-Nrf2 Signaling Pathway in Atherosclerosis.Balkan medical journal · 2025Article
- Associations Between Soluble Cell Adhesion Molecules and Cardiovascular Comorbidities in Systemic Sclerosis: Implications for Insulin Resistance.Journal of clinical medicine · 2025Article
- Interventional real-time molecular MRI for targeting early myocardial injury in a pig model.Npj imaging · 2025Article
- P-Selectin, Vascular Endothelial Cadherin, and Vascular Cell Adhesion Molecule-1 as Novel Biomarkers for ABO Hemolytic Disease of the Fetus and Newborn.Analytical cellular pathology (Amsterdam) · 2025Article
- Soluble P-Selectin as an Indicator of Cutaneous Microangiopathy in Uncomplicated Young Patients with Type 1 Diabetes.Life (Basel, Switzerland) · 2024Article
- Immunoexpression of aortic endothelial P-selectin and serum apolipoprotein A-1 levels after administration of arabica (Narra J · 2024Article
- The association between plasma levels of sCD40L, sP-selectin, and sICAM-1 and smoking-induced coronary heart disease: A cross-sectional study.JRSM cardiovascular diseaseArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
Abstract
BACKGROUND AND
aimsThe adhesion molecule P-selectin is expressed by endothelial cells and platelets. It is involved in platelet activation and leukocyte adhesion, both important processes in the pathogenesis of atherosclerosis. Our study was designed to assess the predictive value of soluble P-selectin (sP-selectin) on the progression of peripheral atherosclerosis.
methodsThis is an observational, single-center, cohort study that included 443 patients with established cardiovascular disease (CVD) or at least one cardiovascular risk factor. Over a period of 4 years, each patient underwent three-dimensional (3D) ultrasound to assess the plaque volume of the carotid and femoral arteries once per year. In addition, plasma sP-selectin levels were measured at each visit. The association between changes in sP-selectin and peripheral atherosclerotic plaque progression was assessed using growth curve models.
results338 patients were available for statistical analysis. Each standard deviation increase in sP-selectin was significantly (
conclusionsIncreasing sP-selectin levels can predict higher atherosclerotic plaque progression as measured by 3D ultrasound. We suggest serial measurements of sP-selectin as an easily measurable biomarker for peripheral atherosclerotic plaque progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.