Evidence map›Paper›PMID 37892524›Full record

ArticleNutrients2023

Administration of Linoleoylethanolamide Reduced Weight Gain, Dyslipidemia, and Inflammation Associated with High-Fat-Diet-Induced Obesity.

Rubén Tovar, Marialuisa de Ceglia, Massimo Ubaldi, Miguel Rodríguez-Pozo, Laura Soverchia, Carlo Cifani, Gema Rojo, Ana Gavito, Laura Hernandez-Folgado, Nadine Jagerovic and 4 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
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  5. An olive oil-derived NAE mixture (OlaliamidBMC veterinary research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Rubén TovarGrupo de Neuropsicofarmacología, Instituto IBIMA-Plataforma BIONAND, Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Avda, Carlos Haya 82, Sótano, 29010 Málaga, Spain.
Marialuisa de CegliaGrupo de Neuropsicofarmacología, Instituto IBIMA-Plataforma BIONAND, Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Avda, Carlos Haya 82, Sótano, 29010 Málaga, Spain.ORCID 0000-0003-4256-7702
Massimo UbaldiSchool of Pharmacy, Pharmacology Unit, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0002-4089-2483
Miguel Rodríguez-PozoGrupo de Neuropsicofarmacología, Instituto IBIMA-Plataforma BIONAND, Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Avda, Carlos Haya 82, Sótano, 29010 Málaga, Spain.ORCID 0009-0007-5276-6082
Laura SoverchiaSchool of Pharmacy, Pharmacology Unit, University of Camerino, 62032 Camerino, Italy.
Carlo CifaniSchool of Pharmacy, Pharmacology Unit, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0001-6180-828X
Gema RojoDepartment of Endocrinology and Nutrition, Hospital Regional Universitario de Málaga, Instituto IBIMA-Plataforma BIONAND, 29010 Málaga, Spain.ORCID 0000-0003-2179-2134
Ana GavitoGrupo de Neuropsicofarmacología, Instituto IBIMA-Plataforma BIONAND, Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Avda, Carlos Haya 82, Sótano, 29010 Málaga, Spain.
Laura Hernandez-FolgadoInstituto de Química Médica, Consejo Superior de Investigaciones Científicas, Avenida Juan de la Cierva, 28006 Madrid, Spain.
Nadine JagerovicInstituto de Química Médica, Consejo Superior de Investigaciones Científicas, Avenida Juan de la Cierva, 28006 Madrid, Spain.ORCID 0000-0003-2642-6969
Roberto CiccocioppoSchool of Pharmacy, Pharmacology Unit, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0003-3126-9240
Elena BaixerasGrupo de Neuropsicofarmacología, Instituto IBIMA-Plataforma BIONAND, Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Avda, Carlos Haya 82, Sótano, 29010 Málaga, Spain.ORCID 0000-0001-6955-2434
Fernando Rodríguez de FonsecaGrupo de Neuropsicofarmacología, Instituto IBIMA-Plataforma BIONAND, Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Avda, Carlos Haya 82, Sótano, 29010 Málaga, Spain.ORCID 0000-0002-4516-5795
Juan DecaraGrupo de Neuropsicofarmacología, Instituto IBIMA-Plataforma BIONAND, Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Avda, Carlos Haya 82, Sótano, 29010 Málaga, Spain.ORCID 0000-0002-9868-015X
Hospital Regional Universitario de Málaga · ESUniversità di Camerino · ITConsejo Superior de Investigaciones Científicas · ES

Funding

INSTITUTO DE SALUD CARLOS III CP21/00021INSTITUTO DE SALUD CARLOS III PI22/00427Ministerio de Educación Cultura y Deporte "Jose Castillejo" Program (Grant CAS15/00257)
6 · The paper itself

Abstract

Acylethanolamides (NAEs) are bioactive lipids derived from diet fatty acids that modulate important homeostatic functions, including appetite, fatty acid synthesis, mitochondrial respiration, inflammation, and nociception. Among the naturally circulating NAEs, the pharmacology of those derived from either arachidonic acid (Anandamide), oleic acid (OEA), and palmitic acid (PEA) have been extensively characterized in diet-induced obesity. For the present work, we extended those studies to linoleoylethanolamide (LEA), one of the most abundant NAEs found not only in plasma and body tissues but also in foods such as cereals. In our initial study, circulating concentrations of LEA were found to be elevated in overweight humans (body mass index (BMI, Kg/m

Indexed as

DyslipidemiasNon-alcoholic Fatty Liver DiseaseAnimalsCholesterolDiet, High-FatHumansInflammationLinoleic AcidsLiverMaleObesityOleic AcidPolyunsaturated AlkamidesRatsRats, Sprague-DawleyTriglyceridesCholesterolLinoleic Acidslinoleoyl ethanolamideOleic AcidPolyunsaturated AlkamidesTriglyceridesacylethanolamideshigh-fat dietlinoleic acidlinoleylethanolamideliver steatosisobesity

Identifiers

PMID37892524
PMCPMC10609991
OpenAlexW4387812175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.