Evidence map›Paper›PMID 37892217›Full record

ReviewBiomolecules2023

Emerging Roles for Dendritic Cells in Heart Failure.

Danish Saleh, Rebecca T L Jones, Samantha L Schroth, Edward B Thorp, Matthew J Feinstein

Open access · goldAbstract readReview
In one paragraph

Review in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Danish SalehDepartment of Medicine, Division of Cardiology, Feinberg School of Medicine, Chicago, IL 60611, USA.
Rebecca T L JonesDepartment of Pathology, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-0970-1968
Samantha L SchrothDepartment of Pathology, Northwestern University, Chicago, IL 60611, USA.
Edward B ThorpDepartment of Pathology, Northwestern University, Chicago, IL 60611, USA.
Matthew J FeinsteinDepartment of Medicine, Division of Cardiology, Feinberg School of Medicine, Chicago, IL 60611, USA.
Northwestern University · US

Funding

Efferocytosis-Directed Inflammation Resolution and Repair in the Hypoxic HeartR01HL122309 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI THORP, EDWARD BENJAMIN · 2014 to 2024
$5.0M
Contributions of Myeloid Metabolism to Diastolic DysfunctionR01HL159964 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI THORP, EDWARD BENJAMIN · 2022 to 2024
$1.5M
NHLBI NIH HHS R01 HL122309NHLBI NIH HHS R01 HL159964
6 · The paper itself

Abstract

The field of cardio-immunology has emerged from discoveries that define roles for innate and adaptive immune responses associated with myocardial inflammation and heart failure. Dendritic cells (DCs) comprise an important cellular compartment that contributes to systemic immune surveillance at the junction of innate and adaptive immunity. Once described as a singular immune subset, we now appreciate that DCs consist of a heterogeneous pool of subpopulations, each with distinct effector functions that can uniquely regulate the acute and chronic inflammatory response. Nevertheless, the cardiovascular-specific context involving DCs in negotiating the biological response to myocardial injury is not well understood. Herein, we review our current understanding of the role of DCs in cardiac inflammation and heart failure, including gaps in knowledge and clinical relevance.

Indexed as

Heart FailureMyocarditisAdaptive ImmunityDendritic CellsHumansInflammationcardio-immunologydendritic cellsdilated cardiomyopathyheart failureheart-failure with preserved ejection fraction (HFpEF)hypertensive heart diseaseischemic cardiomyopathymyocardial inflammationmyocarditisT cells

Identifiers

PMID37892217
PMCPMC10605025
OpenAlexW4387707110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.