Evidence map›Paper›PMID 37892155›Full record

ArticleBiomolecules2023

On Fusogenicity of Positively Charged Phased-Separated Lipid Vesicles: Experiments and Computational Simulations.

Yifei Wang, Yerbol Palzhanov, Dang T Dang, Annalisa Quaini, Maxim Olshanskii, Sheereen Majd

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yifei WangDepartment of Biomedical Engineering, University of Houston, 3551 Cullen Blvd, Houston, TX 77204, USA.
Yerbol PalzhanovDepartment of Mathematics, University of Houston, 3551 Cullen Blvd, Houston, TX 77204, USA.
Dang T DangDepartment of Biomedical Engineering, University of Houston, 3551 Cullen Blvd, Houston, TX 77204, USA.ORCID 0000-0002-3028-7482
Annalisa QuainiDepartment of Mathematics, University of Houston, 3551 Cullen Blvd, Houston, TX 77204, USA.
Maxim OlshanskiiDepartment of Mathematics, University of Houston, 3551 Cullen Blvd, Houston, TX 77204, USA.
Sheereen MajdDepartment of Biomedical Engineering, University of Houston, 3551 Cullen Blvd, Houston, TX 77204, USA.

Funding

US National Science Foundation (NSF DMS-2309197US National Science Foundation (NSF) DMR-1753328US National Science Foundation (NSF) DMS-1953535
6 · The paper itself

Abstract

This paper studies the fusogenicity of cationic liposomes in relation to their surface distribution of cationic lipids and utilizes membrane phase separation to control this surface distribution. It is found that concentrating the cationic lipids into small surface patches on liposomes, through phase-separation, can enhance liposome's fusogenicity. Further concentrating these lipids into smaller patches on the surface of liposomes led to an increased level of fusogenicity. These experimental findings are supported by numerical simulations using a mathematical model for phase-separated charged liposomes. Findings of this study may be used for design and development of highly fusogenic liposomes with minimal level of toxicity.

Indexed as

LipidsLiposomesLipidsLiposomescationic lipidscomputational modelingfluorescence microscopyfusogenic liposomesmembrane phase separation

Identifiers

PMID37892155
PMCPMC10605210

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.