Evidence map›Paper›PMID 37892137›Full record

ArticleBiomolecules2023

KDM2A Deficiency in the Liver Promotes Abnormal Liver Function and Potential Liver Damage.

Matthew Martin, Aishat Motolani, Hyeong-Geug Kim, Amy M Collins, Faranak Alipourgivi, Jiamin Jin, Han Wei, Barry A Wood, Yao-Ying Ma, X Charlie Dong and 2 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Matthew MartinDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA.
Aishat MotolaniDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA.
Hyeong-Geug KimDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Amy M CollinsDepartment of Pathology and Laboratory Medicine, Indiana University Health, Indianapolis, IN 46202, USA.
Faranak AlipourgiviDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA.
Jiamin JinDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA.
Han WeiDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA.
Barry A WoodDepartment of Pathology and Laboratory Medicine, Indiana University Health, Indianapolis, IN 46202, USA.
Yao-Ying MaDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA.
X Charlie DongDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Raghavendra G MirmiraUniversity of Chicago Medicine Kovler Diabetes Center, Chicago, IL 60637, USA.ORCID 0000-0002-5013-6075
Tao LuDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA.ORCID 0000-0002-0013-4987
Indiana University School of MedicineIndiana University Health · USUniversity of Chicago · US

Funding

Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI RONALD N COHEN · 2013 to 2026
$20.9M
Transcriptional Mechanisms Governing Beta Cell DifferentiationR01DK060581 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Raghavendra G Mirmira · 2002 to 2026
$8.5M
Validation of small molecule 12-lipoxygenase inhibitors in metabolic diseaseR01DK105588 · NIDDK · UNIVERSITY OF CHICAGO · PI KULKARNI, ROHIT N., MIRMIRA, RAGHAVENDRA G · 2015 to 2024
$5.5M
Epigenetic regulation in liver fibrosisR01DK121925 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI DONG, X. CHARLIE · 2020 to 2023
$1.8M
Role of ATG14 in the regulation of hepatic functionR01DK120689 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI DONG, X. CHARLIE · 2020 to 2023
$1.7M
Gene-specific responses to NF-kB through lysine and arginine methylation of p65R01GM120156 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI LU, TAO · 2017 to 2021
$1.5M
NIDDK NIH HHS P30 DK020595NIDDK NIH HHS R01 DK060581NIDDK NIH HHS R01 DK105588NIDDK NIH HHS R01 DK120689NIDDK NIH HHS R01 DK121925NIGMS NIH HHS R01 GM120156
6 · The paper itself

Abstract

Dysregulation of metabolic functions in the liver impacts the development of diabetes and metabolic disorders. Normal liver function can be compromised by increased inflammation via the activation of signaling such as nuclear factor (NF)-κB signaling. Notably, we have previously identified lysine demethylase 2A (KDM2A)-as a critical negative regulator of NF-κB. However, there are no studies demonstrating the effect of KDM2A on liver function. Here, we established a novel liver-specific

Indexed as

Liver DiseasesNF-kappa BAnimalsInflammationLiverMiceSignal TransductionNF-kappa BdiabetesKDM2AlivermetabolismNF-κB

Identifiers

PMID37892137
PMCPMC10604476
OpenAlexW4387100853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.