Evidence map›Paper›PMID 37892134›Full record

ReviewBiomolecules2023

Insights into COVID-19: Perspectives on Drug Remedies and Host Cell Responses.

Ahmed M Awad, Kamryn Hansen, Diana Del Rio, Derek Flores, Reham F Barghash, Laura Kakkola, Ilkka Julkunen, Kareem Awad

Abstract readReview
In one paragraph

Review in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ahmed M AwadDepartment of Chemistry, California State University Channel Islands, Camarillo, CA 93012, USA.ORCID 0000-0002-6991-9336
Kamryn HansenDepartment of Chemistry, California State University Channel Islands, Camarillo, CA 93012, USA.
Diana Del RioDepartment of Chemistry, California State University Channel Islands, Camarillo, CA 93012, USA.
Derek FloresDepartment of Chemistry, California State University Channel Islands, Camarillo, CA 93012, USA.
Reham F BarghashInstitute of Chemical Industries Research, National Research Centre, Dokki, Cairo 12622, Egypt.ORCID 0000-0003-2731-9970
Laura KakkolaInstitute of Biomedicine, Faculty of Medicine, University of Turku, 20014 Turku, Finland.ORCID 0000-0001-9271-4059
Ilkka JulkunenInstitute of Biomedicine, Faculty of Medicine, University of Turku, 20014 Turku, Finland.ORCID 0000-0003-0165-2564
Kareem AwadInstitute of Biomedicine, Faculty of Medicine, University of Turku, 20014 Turku, Finland.ORCID 0000-0003-1007-9632

Funding

National Science Foundation IUSE 1928693
6 · The paper itself

Abstract

In light of the COVID-19 global pandemic caused by SARS-CoV-2, ongoing research has centered on minimizing viral spread either by stopping viral entry or inhibiting viral replication. Repurposing antiviral drugs, typically nucleoside analogs, has proven successful at inhibiting virus replication. This review summarizes current information regarding coronavirus classification and characterization and presents the broad clinical consequences of SARS-CoV-2 activation of the angiotensin-converting enzyme 2 (ACE2) receptor expressed in different human cell types. It provides publicly available knowledge on the chemical nature of proposed therapeutics and their target biomolecules to assist in the identification of potentially new drugs for the treatment of SARS-CoV-2 infection.

Indexed as

COVID-19Antiviral AgentsHumansPeptidyl-Dipeptidase ASARS-CoV-2Virus InternalizationAntiviral AgentsPeptidyl-Dipeptidase AACE2coronavirusCOVID-19drug designnucleoside analogstarget cell responses

Identifiers

PMID37892134
PMCPMC10604481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.