Evidence map›Paper›PMID 37892074›Full record

ArticleDiagnostics (Basel, Switzerland)2023

More Than a Decade of GeneXpert

Manuel Pedro da Silva, Naseem Cassim, Silence Ndlovu, Puleng Shiela Marokane, Mbuti Radebe, Anne Shapiro, Lesley Erica Scott, Wendy Susan Stevens

Abstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Risk of Tuberculosis Infection in Young Children Exposed to Multidrug-resistant Tuberculosis in the TB-CHAMP Multi-site Randomized Controlled Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Trial
  2. Closing gaps through innovation in the tuberculosis pathology value chain.Journal of clinical tuberculosis and other mycobacterial diseases · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Rifampicin-resistantJournal of clinical tuberculosis and other mycobacterial diseases · 2025
    Article
  8. Article
  9. Xpert MTB/RIF Ultra 'trace': considerations for diagnostics.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2025
    Article
  10. Observational
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Retrospective analysis of CD4 count trends in South Africa.Southern African journal of HIV medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Manuel Pedro da SilvaNational Health Laboratory Service (NHLS), Johannesburg 2192, South Africa.ORCID 0000-0002-9869-5271
Naseem CassimNational Health Laboratory Service (NHLS), Johannesburg 2192, South Africa.ORCID 0000-0003-4389-2849
Silence NdlovuNational Health Laboratory Service (NHLS), Johannesburg 2192, South Africa.
Puleng Shiela MarokaneNational Health Laboratory Service (NHLS), Johannesburg 2192, South Africa.
Mbuti RadebeNational Health Laboratory Service (NHLS), Johannesburg 2192, South Africa.
Anne ShapiroDepartment of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.ORCID 0000-0002-5917-1440
Lesley Erica ScottWits Diagnostics Innovation Hub (DIH), Faculty of Health Sciences, University of Witwatersrand, Johannesburg 2193, South Africa.ORCID 0000-0001-6573-9525
Wendy Susan StevensNational Health Laboratory Service (NHLS), Johannesburg 2192, South Africa.

Funding

Evaluating the tuberculosis epidemic in South Africa using a novel ten-year cohortR01AI152126 · NIAID · WITS HEALTH CONSORTIUM (PTY), LTD · PI JENKINS, HELEN E., SCOTT, LESLEY · 2020 to 2024
$1.6M
NIAID NIH HHS R01 AI152126
6 · The paper itself

Abstract

This study seeks to describe the rollout and current state of South Africa's GeneXpert molecular diagnostic program for tuberculosis (TB). Xpert MTB/RIF was introduced in 2011 with a subsequent expansion to include extra-pulmonary and paediatric testing, followed by Xpert MTB/RIF Ultra in 2017. Through a centralised laboratory information system and the use of a standardised platform for more than a decade, over 23 million tests were analysed, describing the numbers tested,

Indexed as

extra-pulmonary tuberculosisGeneXpert MTB/RIFGeneXpert MTB/RIF Ultraimplementationmolecular diagnosticspulmonary tuberculosisspecimen typestuberculosis

Identifiers

PMID37892074
PMCPMC10605857

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.