ArticleAntioxidants (Basel, Switzerland)2023
Smoking Induces a Decline in Semen Quality and the Activation of Stress Response Pathways in Sperm.
Article in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 22 citations in OpenAlex.
- Antioxidant Capacity of Seminal Plasma and Its Association with Semen Quality and Dietary Antioxidant Intake.Nutrients · 2026Article
- The necessity of understanding the seriousness of the impact of smoking on reproductive health: A letter to the editor.International journal of reproductive biomedicine · 2026Article
- Epidemiological, Clinical, and Biomarker Profile of Male Infertility in Morocco: A Retrospective Single-Center Study of 1399 Cases.Diseases (Basel, Switzerland) · 2025Article
- Evaluating the effect of smoking and its cessation on semen parameters.Reproduction & fertility · 2025Article
- Exposure to ambient particulate matter and semen quality: the modifying role of socioeconomic status and lifestyle factors in chinese men.BMC public health · 2025Article
- Systemic impacts of diabetes on spermatogenesis and intervention strategies: multilayered mechanism analysis and cutting-edge therapeutic approaches.Reproductive biology and endocrinology : RB&E · 2025Review
- Observational
- Understanding the impact of lifestyle and demographic factors on DNA fragmentation index (DFI) among infertile men.BMC urology · 2025Article
- The Androbactome and the Gut Microbiota-Testis Axis: A Narrative Review of Emerging Insights into Male Fertility.International journal of molecular sciences · 2025Review
- Ferroptotic- and non-ferroptotic mechanisms associated with doxorubicin-induced male reproductive dysfunction.Toxicology reports · 2025Review
- Impact of Tobacco Cigarette Smoking on Semen Quality and Serum Levels of Sex Hormones in Men: A Cross-Sectional Population-Based Study.Health science reports · 2025Article
- Adverse Effects of Nicotine on Human Sperm Nuclear Proteins.The world journal of men's health · 2025Review
- How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development, and offspring health.Clinical epigenetics · 2025Review
- Semen Quality Measures in Hookah and Cigarette Smokers Compared to Nonsmokers.TheScientificWorldJournal · 2025Article
- Empirical Treatments for Male Infertility: A Focus on Lifestyle Modifications and Medicines.Diseases (Basel, Switzerland) · 2024Review
- Association between serum cotinine levels and urinary incontinence in adults in the United States: a population-based cross-sectional analysis.BMC public health · 2024Article
- Advancements in Genetic Biomarkers and Exogenous Antioxidant Supplementation for Safeguarding Mammalian Cells against Heat-Induced Oxidative Stress and Apoptosis.Antioxidants (Basel, Switzerland) · 2024Review
- Exploring altered bovine sperm trajectories by sperm tracking in unconfined conditions.Frontiers in veterinary science · 2024Article
- Reassessing Semen Analysis: Clinical Insights Beyond Sperm Count and Motility.Reproductive medicine and biologyReview
- Occupational Heat Exposure and Fertility Stress as Independent Factors of Low Semen Quality: A Multidimensional Analysis.American journal of men's healthArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Male infertility is a prevalent concern affecting couples worldwide. While genetic factors, hormonal imbalances, and reproductive system defects play significant roles, emerging evidence suggests that lifestyle choices also profoundly impact male fertility. This study aimed to explore the effects of several lifestyle factors, including tobacco and alcohol consumption, physical activity, and dietary habits, on semen quality parameters and molecular biomarkers. Thirty healthy male volunteers were recruited in the Urology service at Hospital Infante D. Pedro, Aveiro, Portugal. Participants completed lifestyle questionnaires and provided semen samples, which were analyzed according to the World Health Organization criteria by experienced technicians. We also analyzed the expression levels of antioxidant enzymes and heat-shock response-related proteins to explore the activation of signaling pathways involved in stress response within sperm cells. Our results revealed that tobacco consumption reduced semen volume and total sperm count. Although the changes in the percentage of total motility and normal morphology in the smokers' group did not reach statistical significance, a slight decrease was observed. Moreover, we identified for the first time a significant association between tobacco consumption and increased levels of heat shock protein 27 (HSP27) and phosphorylated HSP27 (p-HSP27) in sperm cells, indicating the potential detrimental effects of tobacco on the reproductive system. This study highlights that lifestyle factors reduce semen quality, possibly by inducing stress in sperm, raising awareness about the effects of these risk factors among populations at risk of male infertility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.