ArticleBrain sciences2023
Prefrontal Glutathione Levels in Major Depressive Disorder Are Linked to a Lack of Positive Affect.
Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.
- Glutathione-Related Metabolite Levels and Enzyme Activities in Depression: A Systematic Review and Meta-Analysis.Neuropsychopharmacology reports · 2026Pooled it
- Glutathione alterations in depression: a meta-analysis and systematic review of proton magnetic resonance spectroscopy studies.Psychopharmacology · 2025Pooled it
- Association between Cortical Gyrification and Major Depression: Clinical Correlates.Psychopathology · 2026Article
- The Role of Various Types of Diets in the Treatments of Depressive Disorders.Medicina (Kaunas, Lithuania) · 2025Review
- Investigating low intensity focused ultrasound pulsation in anhedonic depression-A randomized controlled trial.Frontiers in human neuroscience · 2025Article
- Detecting depression severity using weighted random forest and oxidative stress biomarkers.Scientific reports · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major depressive disorder (MDD) is one of the most common neuropsychiatric disorders, with symptoms including persistent sadness and loss of interest. MDD is associated with neurochemical alterations in GABA, glutamate, and glutamine levels but, to date, few studies have examined changes in glutathione (GSH) in MDD. This study investigated changes in GSH in an unmedicated group of young adults, including 46 participants with current (
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.