Evidence map›Paper›PMID 37891681›Full record

ArticlePilot and feasibility studies2023

PEERNaija-a mobile health platform incentivizing medication adherence among youth living with HIV in Nigeria: study protocol for a randomized controlled trial.

Leslie J Pierce, Martin C Were, Sandra Amaral, Muktar H Aliyu, Oliver Ezechi, Agatha David, Ifeoma Idigbe, Adesola Z Musa, Prosper Okonkwo, Nadia Dowshen and 1 more

Registry-linked trialAbstract read
In one paragraph

Article in Pilot and feasibility studies, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04930198 (PeerNaija), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04930198 nacompletednot on this map

PeerNaija: A Mobile Health Platform Incentivizing Medication Adherence Among Youth Living With HIV in Nigeria

TypeinterventionalSponsorVanderbilt University Medical CenterRan2021 to 2024Enrolled54ConditionsHIV/AIDSArmsPeerNaija
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. User-centered adaption ofAIDS care · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Leslie J PierceVanderbilt Institute for Global Health, Vanderbilt University Medical Center, Nashville, TN, USA.
Martin C WereVanderbilt Institute for Global Health, Vanderbilt University Medical Center, Nashville, TN, USA.
Sandra AmaralDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Muktar H AliyuVanderbilt Institute for Global Health, Vanderbilt University Medical Center, Nashville, TN, USA.
Oliver EzechiNigerian Institute of Medical Research, Lagos, Nigeria.
Agatha DavidNigerian Institute of Medical Research, Lagos, Nigeria.
Ifeoma IdigbeNigerian Institute of Medical Research, Lagos, Nigeria.
Adesola Z MusaNigerian Institute of Medical Research, Lagos, Nigeria.
Prosper OkonkwoAPIN Public Health Initiatives (APIN), Abuja, Nigeria.
Nadia DowshenCraig-Dalsimer Division of Adolescent Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Aima A AhonkhaiVanderbilt Institute for Global Health, Vanderbilt University Medical Center, Nashville, TN, USA. aimalohi.a.ahonkhai@vumc.org.ORCID http://orcid.org/0000-0003-0666-4767

Funding

Training Program on HIV and Substance Use in the Criminal Justice SystemT32DA037801 · NIDA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Nabila El-Bassel, Lisa R Metsch · 2014 to 2026
$5.7M
HIV Intervention Science Training Program for Underserved Investigators R25MH080665 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI EL-BASSEL, NABILA, WU, ELWIN · 2007 to 2023
$2.8M
Maternal mHealth blood hemoglobin analysis with informed deep learningR01EB033788 · NIBIB · PURDUE UNIVERSITY · PI Young L Kim, Martin Chieng Were · 2023 to 2026
$2.0M
PeerNaija: A Mobile Health Platform Incentivizing Medication Adherence Among Youth Living with HIV in NigeriaR21TW011327 · FIC · VANDERBILT UNIVERSITY MEDICAL CENTER · PI AHONKHAI, AIMALOHI, WERE, MARTIN CHIENG · 2019 to 2020
$428k
FIC NIH HHS NIH/FIC R21 TW011327FIC NIH HHS R21 TW011327NIBIB NIH HHS R01 EB033788NIDA NIH HHS T32 DA037801NIMH NIH HHS R25MH08065NIMH NIH HHS R25 MH080665
6 · The paper itself

Abstract

backgroundPoor medication adherence is a major barrier to HIV control among youth living with HIV (Y-PLWH). The PEERNaija application (app) is an adapted smartphone app grounded in social cognitive and contigency management theories and designed to harness peer-based social incentives and conditional financial incentives to promote medication adherence. The app delivers a multifaceted medication adherence intervention including (1) peer-based social incentives, (2) financial incentives, (3) virtual peer social support, and (4) early clinic-based outreach for non-adherent Y-PLWH. A pilot trial of the app will be conducted in Nigeria, Africa's most populous country with the 4th largest HIV epidemic, and home to 10% of the world's four million Y-PLWH.

methodsIn this randomized controlled trial, we will compare implementation outcomes (feasibility, acceptability, appropriateness measured via validated scales, enrollment and application installation rates, feedback surveys and focus group discussions with participants, and back-end application data), and preliminary efficacy (in improving medication adherence and viral suppression) of the PEERNaija app at 6 months. Participants in Arm 1 (PEERNaija) will receive daily medication reminders, peer-based social incentives, and virtual peer social support. Participants in Arm 2 (PEERNaija +) will additionally receive a conditional financial incentive based on their adherence performance. Eligibility for Y-PLWH includes (1) being aged 14-29 years, (2) being on ART, (3) owning a smartphone, (4) being willing to download an app, and (5) being able to read simple text in English. DISCUSSION: This study will serve as the basis for a larger intervention trial evaluating the PEERNaija app (and the integration of mHealth, incentive, and peer-support-based strategies) to improve HIV outcomes in a critically important region of the world for Y-PLWH.

trial registrationClinicalTrials.gov. NCT04930198. First submitted date: May 25, 2021. Study start: August 1, 2021, https://clinicaltrials.gov/ . PROTOCOL VERSION: January 21, 2022.

Indexed as

AdherenceHIVMobile healthYoung adults

Identifiers

PMID37891681
PMCPMC10605971

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.