Evidence map›Paper›PMID 37891594›Full record

ArticleVirology journal2023

A fatal case of neonatal viral sepsis caused by human parainfluenza virus type 3.

Xiangpeng Chen, Hong Wang, Qi Li, Yujie Qi, Fei Li, Wenwen He, Qiushi Wang, Fei Jin, Yanqing Guo, Mingyan Hei and 1 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Xiangpeng Chen *Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Research Unit of Critical Infection in Children, Laboratory of Infection and Virology, Beijing Children's Hospital, Chinese Academy of Medical Sciences, Beijing Pediatric Research Institute, Capital Medical University, National Center for Children's Health, No. 56 Nan-li-shi Road, Xicheng District, Beijing, 2019RU016, 100045, China.
Hong Wang *Department of Neonatology, Neonatal Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Qi LiBeijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Research Unit of Critical Infection in Children, Laboratory of Infection and Virology, Beijing Children's Hospital, Chinese Academy of Medical Sciences, Beijing Pediatric Research Institute, Capital Medical University, National Center for Children's Health, No. 56 Nan-li-shi Road, Xicheng District, Beijing, 2019RU016, 100045, China.
Yujie QiDepartment of Neonatology, Neonatal Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Fei LiBeijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Research Unit of Critical Infection in Children, Laboratory of Infection and Virology, Beijing Children's Hospital, Chinese Academy of Medical Sciences, Beijing Pediatric Research Institute, Capital Medical University, National Center for Children's Health, No. 56 Nan-li-shi Road, Xicheng District, Beijing, 2019RU016, 100045, China.
Wenwen HeDepartment of Neonatology, Neonatal Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Qiushi WangInfection Business Unit, Tianjin Novogene Med LAB Co., Ltd, Tianjin, 301700, China.
Fei JinDepartment of Neonatology, Neonatal Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Yanqing GuoInfection Business Unit, Tianjin Novogene Med LAB Co., Ltd, Tianjin, 301700, China.
Mingyan HeiDepartment of Neonatology, Neonatal Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. heimingyan@bch.com.cn.
Zhengde XieBeijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Research Unit of Critical Infection in Children, Laboratory of Infection and Virology, Beijing Children's Hospital, Chinese Academy of Medical Sciences, Beijing Pediatric Research Institute, Capital Medical University, National Center for Children's Health, No. 56 Nan-li-shi Road, Xicheng District, Beijing, 2019RU016, 100045, China. xiezhengde@bch.com.cn.
Capital Medical University · CNBeijing Children’s Hospital · CNNovogene Bioinformatics Institute · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSepsis is a systemic inflammatory response syndrome caused by severe infection in children, but cases of sepsis associated with human parainfluenza virus (HPIV) have been rarely reported in newborns. CASE PRESENTATION: We report a case of HPIV-3 positive full-term newborn admitted to the Neonatal Intensive Care Unit of Beijing Children's Hospital due to hematuria, gloomy spirit, inactivity and loss of appetite for 6 h. He had septic shock when he arrived the Accident & Emergency Department requiring immediate intubation and mechanical ventilation. Intravenous antibiotics were started. He had completely negative response to all anti-shock treatments including fluid resuscitation and vasopressor supports, and died 14 h later. Viral nucleic acid detection and metagenomic next-generation sequencing (mNGS) analyses of nasopharyngeal aspirate and blood specimens verified an HPIV-3 infection, with negative bacterial culture results. The HPIV-3 strain detected in this patient was subtyped as HPIV C3a, and two unreported amino acid mutations were found in the HN protein region.

conclusionThe patient had a severe infection associated with HPIV-3, which was the cause of sepsis and septic shock. This study showed the diagnostic value of mNGS in etiological diagnosis, especially in severe neonatal case.

Indexed as

Respiratory Tract InfectionsShock, SepticChildHumansInfant, NewbornMaleMutationParainfluenza Virus 2, HumanParainfluenza Virus 3, HumanViremiaHuman parainfluenza virusSepsisSeptic shock

Identifiers

PMID37891594
PMCPMC10612315
OpenAlexW4387996339

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.