ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2024
Global, regional and national burden of ischemic stroke attributed to high low-density lipoprotein cholesterol, 1990-2019：A decomposition analysis and age-period-cohort analysis.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of cognitive-motor interventions on serum BDNF levels in adults and older population post-stroke: a systematic review and meta-analysis of randomized controlled trials.Frontiers in pharmacology · 2026Pooled it
- Lipidomic profiling identifies key pathways and a 5-lipid panel with high diagnostic efficacy for ischemic stroke.Scientific reports · 2026Article
- Analysis of the correlation between the serum residual cholesterol level at admission and the risk of death after discharge in patients with ischemic stroke.Journal of medical biochemistry · 2026Article
- Decomposition Analysis of High BMI-Attributable Stroke Burden in China: Population Aging as the Dominant Driver.Journal of obesity · 2026Article
- Stroke burden in North Africa and the Middle East, 1990-2021: an analysis based on the global burden of disease study.BMC neurology · 2025Article
- Burden of ischemic stroke attributable to high low-density lipoprotein cholesterol in China from the global burden of disease study 2021.Scientific reports · 2025Article
- Risk factors and predictive model for gastrointestinal bleeding in patients with ischemic stroke: a case-control study.American journal of translational research · 2025Article
- Global, regional, and national burden and trends of stroke among youths and young adults aged 15-39 years from 1990 to 2021: findings from the Global Burden of Disease study 2021.Frontiers in neurology · 2025Article
- Systematic analysis of the burden of ischemic stroke attributable to high LDL-C from 1990 to 2021.Frontiers in neurology · 2025Article
- Global, regional, and national trends in ischaemic stroke burden and risk factors among adults aged 20 + years (1990-2021): a systematic analysis of data from the Global Burden of Disease study 2021 with projections into 2050.Frontiers in public health · 2025Article
- Comparing burden of ischemic stroke caused by high low-density lipoprotein cholesterol in global and China: trends and projections.Frontiers in neurology · 2025Article
- Impact of population ageing on cancer-related disability-adjusted life years: A global decomposition analysis.Journal of global health · 2024Article
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7 authors.
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Abstract
High levels of low-density lipoprotein cholesterol (LDL-C) have been associated with an augmented mortality of ischemic stroke. The yearly deaths and mortality data of IS-hLDL-C were derived from the global burden of disease 2019 dataset. The joinpoint, age-period-cohort and decomposition analysis were utilized to evaluate the long-term patterns in the disease burden of IS-hLDL-C, and the effects of population growth and aging. Globally, in 2019, 0.61 million ischemic stroke-related deaths were attributable to high LDL-C, with the highest death burden in the high-middle socio-demographic index (SDI) region. From 1990 to 2019, the age-standardized death rate (ASDR) for IS-hLDL-C exhibited a downward trend, with an average annual percentage change of -1.69 [95% confidence interval: -1.90, -1.48)]. The fastest decreasing trends in ASDR were experienced in the high SDI region. In 119 (58.33%) countries, aging increased the disease burden of hLDL-IS, and population growth increased the disease burden of IS-hLDL-C in 163 (79.90%) countries. The trend in disease burden of IS-hLDL-C exhibited variation across countries and regions, particularly in territories with high to middle high SDI. Aging in upper to middle-income countries and population growth in low to middle-income countries further offset endeavors to reduce the burden of ischemic stroke deaths.
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