ArticleNature communications2023
Gut microbiota impacts bone via Bacteroides vulgatus-valeric acid-related pathways.
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Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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60citing papers in PubMed
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60 citing papers in PubMed, 73 citations in OpenAlex.
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- Osteoporosis from the perspective of the gut-bone axis: gut microbiota, metabolites, and multi-system synergistic regulation.Journal of endocrinological investigation · 2026Review
- Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Links between bone fractures and the gut microbiota.Nature reviews. Endocrinology · 2026Review
- Association of a Novel Dietary Index Assessing Gut Microbiota Impact With Rheumatoid Arthritis: A Nationwide Population-Based Study.Food science & nutrition · 2026Article
- Metallic Contaminants and Osteoporosis: a Review of the Gut-Bone Axis.Biological trace element research · 2026Review
- Biochemistry of Human Gut Microbiota: Related Diseases and Dietary Interactions.Molecules (Basel, Switzerland) · 2026Review
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- MST4 as a key driver of osteoclast activation in osteoporosis.Journal of pharmaceutical analysis · 2026Article
- Gut microbiota and bone aging: Focusing on the gut-X axis modes.Journal of orthopaedic translation · 2026Review
- Distinct effects of different Bacteroides strains on depressive-like behavior via a gut-Th1/Th17 cells-brain axis.Communications biology · 2026Article
- Composite dietary fiber alleviates obesity-induced skeletal muscle atrophy by regulating gut microbiota-derived short-chain fatty acids in mice.NPJ science of food · 2026Article
- Dual immunomodulatory effects ofFrontiers in microbiology · 2026Article
- Reduced gut microbial diversity characterized by decreasedFrontiers in cellular and infection microbiology · 2026Observational
- Roles of gut metabolites on bone mineralization and remodeling: impact of metabolic dysregulation on the gut-immune-bone axis.Frontiers in endocrinology · 2026Review
- Interorgan Communications in Skeletal Pathophysiology: From Molecular Pathways to Multidisciplinary Therapies.Research (Washington, D.C.) · 2026Review
- Tryptophan-Restricted Intermittent Diet Alleviates Estrogen Deficiency-Induced Osteoporosis via Regulating Coupling Effects of "Gut-Bone" Axis.International journal of biological sciences · 2026Article
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Authors and funding
32 authors at 8 institutions in 2 countries.
Xu Lin *Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde), No.1 of Jiazi Road, Lunjiao, Shunde District, Foshan City, 528308, Guangdong Province, China.ORCID 0000-0002-8949-1461
Hong-Mei Xiao *Center of System Biology, Data Information and Reproductive Health, School of Basic Medical Science, Central South University, Changsha, 410008, Hunan Province, China. hmxiao@csu.edu.cn.ORCID 0000-0002-8121-9498
Hui-Min LiuCenter of System Biology, Data Information and Reproductive Health, School of Basic Medical Science, Central South University, Changsha, 410008, Hunan Province, China.
Wan-Qiang LvCenter of System Biology, Data Information and Reproductive Health, School of Basic Medical Science, Central South University, Changsha, 410008, Hunan Province, China.ORCID 0000-0001-8620-8889
Jonathan GreenbaumTulane Center for Biomedical Informatics and Genomics, Deming Department of Medicine, School of Medicine, Tulane University, New Orleans, LA, 70112, USA.
Rui GongDepartment of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, Guangdong Province, China.ORCID 0000-0001-9942-5655
Qiang ZhangTulane Center for Biomedical Informatics and Genomics, Deming Department of Medicine, School of Medicine, Tulane University, New Orleans, LA, 70112, USA.
Yuan-Cheng ChenDepartment of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, Guangdong Province, China.
Cheng PengDepartment of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, Guangdong Province, China.ORCID 0000-0002-5359-221X
Xue-Juan XuDepartment of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, Guangdong Province, China.ORCID 0000-0003-1379-480X
Dao-Yan PanDepartment of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, Guangdong Province, China.ORCID 0000-0002-0381-0119
Zhi ChenDepartment of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, Guangdong Province, China.ORCID 0000-0001-9914-6664
Zhang-Fang LiDepartment of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, Guangdong Province, China.ORCID 0000-0001-8455-7970
Rou ZhouDepartment of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, Guangdong Province, China.
Xia-Fang WangDepartment of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, Guangdong Province, China.
Jun-Min LuDepartment of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, Guangdong Province, China.
Zeng-Xin AoDepartment of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, Guangdong Province, China.
Yu-Qian SongDepartment of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, Guangdong Province, China.
Yin-Hua ZhangDepartment of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, Guangdong Province, China.
Kuan-Jui SuTulane Center for Biomedical Informatics and Genomics, Deming Department of Medicine, School of Medicine, Tulane University, New Orleans, LA, 70112, USA.ORCID 0000-0002-5163-9774
Xiang-He MengTulane Center for Biomedical Informatics and Genomics, Deming Department of Medicine, School of Medicine, Tulane University, New Orleans, LA, 70112, USA.ORCID 0000-0001-8731-2899
Chang-Li GeLC-Bio Technologies (Hangzhou) CO., LTD., Hangzhou, 310018, Zhejiang Province, China.ORCID 0000-0001-9374-185X
Feng-Ye LvLC-Bio Technologies (Hangzhou) CO., LTD., Hangzhou, 310018, Zhejiang Province, China.
Zhe LuoTulane Center for Biomedical Informatics and Genomics, Deming Department of Medicine, School of Medicine, Tulane University, New Orleans, LA, 70112, USA.ORCID 0000-0001-6495-408X
Xing-Ming ShiDepartments of Neuroscience & Regenerative Medicine and Orthopaedic Surgery, Medical College of Georgia, Augusta University, Augusta, GA, 30914, USA.ORCID 0000-0003-4920-0989
Qi ZhaoDepartment of Preventive Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.ORCID 0000-0002-5079-1803
Bo-Yi GuoDepartment of Biostatistics, University of Alabama at Birmingham, Alabama, 35294, USA.ORCID 0000-0003-2950-2349
Neng-Jun YiDepartment of Biostatistics, University of Alabama at Birmingham, Alabama, 35294, USA.
Hui ShenTulane Center for Biomedical Informatics and Genomics, Deming Department of Medicine, School of Medicine, Tulane University, New Orleans, LA, 70112, USA.ORCID 0000-0003-0335-6064
Christopher J PapasianDepartment of Biomedical Sciences, School of Medicine, University of Missouri-Kansas City, 2411 Holmes Street, Kansas City, MO, 64108, USA.ORCID 0000-0001-6669-6141
Jie ShenShunde Hospital of Southern Medical University (The First People's Hospital of Shunde), No.1 of Jiazi Road, Lunjiao, Shunde District, Foshan City, 528308, Guangdong Province, China. shenjiedr@163.com.ORCID 0000-0001-6952-9541
Hong-Wen DengTulane Center for Biomedical Informatics and Genomics, Deming Department of Medicine, School of Medicine, Tulane University, New Orleans, LA, 70112, USA. hdeng2@tulane.edu.ORCID 0000-0002-0387-8818
Third Affiliated Hospital of Southern Medical University · CNTulane University · USCentral South University · CNHangzhou DAC Biotech (China) · CNUniversity of Alabama at Birmingham · USAugusta University · USUniversity of Missouri–Kansas City · USUniversity of Tennessee Health Science Center · US
Funding
Tulane COBRE in Cardiometabolic Diseases Clinical Research CoreP20GM109036 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Ning Liu · 2016 to 2026
$25.3MTrans-omics Integration of Multi-omics Studies for OsteoporosisU19AG055373 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI Chuan Qiu · 2017 to 2026
$24.3MIdentification of Metabolomic Profiles for Sarcopenia Traits in Older Whites and BlacksR01AG061917 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SHEN, HUI, ZHAO, QI · 2019 to 2023
$3.0MDecoding Methylation Mediated Epigenomic Contributions to Male OsteoporosisR01AR069055 · NIAMS · TULANE UNIVERSITY OF LOUISIANA · PI DENG, HONG-WEN · 2017 to 2021
$2.9MIntegration of brain imaging with genomic and epigenomic dataR01MH104680 · NIMH · TULANE UNIVERSITY OF LOUISIANA · PI CALHOUN, VINCE D, DENG, HONG-WEN · 2014 to 2017
$2.1MNIAMS NIH HHS R01 AR069055NIA NIH HHS R01 AG061917NIA NIH HHS U19 AG055373NIGMS NIH HHS P20 GM109036NIMH NIH HHS R01 MH104680
Abstract
Although the gut microbiota has been reported to influence osteoporosis risk, the individual species involved, and underlying mechanisms, remain largely unknown. We performed integrative analyses in a Chinese cohort of peri-/post-menopausal women with metagenomics/targeted metabolomics/whole-genome sequencing to identify novel microbiome-related biomarkers for bone health. Bacteroides vulgatus was found to be negatively associated with bone mineral density (BMD), which was validated in US white people. Serum valeric acid (VA), a microbiota derived metabolite, was positively associated with BMD and causally downregulated by B. vulgatus. Ovariectomized mice fed B. vulgatus demonstrated increased bone resorption and poorer bone micro-structure, while those fed VA demonstrated reduced bone resorption and better bone micro-structure. VA suppressed RELA protein production (pro-inflammatory), and enhanced IL10 mRNA expression (anti-inflammatory), leading to suppressed maturation of osteoclast-like cells and enhanced maturation of osteoblasts in vitro. The findings suggest that B. vulgatus and VA may represent promising targets for osteoporosis prevention/treatment.
Indexed as
Bone ResorptionGastrointestinal MicrobiomeOsteoporosisAnimalsBacteroidesFemaleHumansMicePentanoic Acidsn-pentanoic acidPentanoic Acids
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