Evidence map›Paper›PMID 37891217›Full record

ArticleScientific reports2023

Myofascial urinary frequency syndrome is a novel syndrome of bothersome lower urinary tract symptoms associated with myofascial pelvic floor dysfunction.

A Lenore Ackerman, Nicholas J Jackson, Ashley T Caron, Melissa R Kaufman, Jonathan C Routh, Jerry L Lowder

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Article
  3. Bladder and bowel dysfunction in children with sleep bruxism.International urology and nephrology · 2025
    Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

A Lenore AckermanDivision of Pelvic Medicine and Reconstructive Surgery, Department of Urology, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Box 951738, Los Angeles, CA, 90095-1738, USA. AAckerman@mednet.ucla.edu.
Nicholas J JacksonDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Ashley T CaronMichigan State University College of Human Medicine, Grand Rapids, MI, USA.
Melissa R KaufmanDivision of Reconstructive Urology and Pelvic Health, Department of Urology, Vanderbilt University Medical Center, Nashville, TN, USA.
Jonathan C RouthDivision of Urologic Surgery, Duke University School of Medicine, Durham, NC, USA.
Jerry L LowderDepartment of Obstetrics and Gynecology, Division of Female Pelvic Medicine and Reconstructive Surgery, Washington University School of Medicine, St. Louis, USA.
University of California, Los Angeles · USDuke University · USInstitute for Female Pelvic Medicine and Reconstructive Surgery · USMichigan State University · USVanderbilt University Medical Center · US

Funding

UrogynCREST ProgramR25HD094667 · NICHD · DUKE UNIVERSITY · PI Cindy Amundsen · 2019 to 2026
$1.2M
The Urinary Microbiota and Host Inflammation in Lower Urinary Tract SymptomsK08DK118176 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ACKERMAN, A. LENORE · 2019 to 2023
$839k
The Role of the Vaginal Microbiota in Urgency Urinary Incontinence in Older WomenR03AG067993 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ACKERMAN, A. LENORE · 2020 to 2021
$323k
NIA NIH HHS R03 AG067993NICHD NIH HHS R25 HD094667NIDDK NIH HHS K08 DK118176
6 · The paper itself

Abstract

This study describes a novel, distinct phenotype of urinary symptoms named "myofascial urinary frequency syndrome" (MUFS) present in one-third of individuals presenting with urinary frequency. In addition to a characteristic symptom constellation suggestive of myofascial dysfunction, MUFS subjects exhibit "persistency": a persistent feeling of needing to urinate regardless of urine volume. On examination, 97% of MUFS patients demonstrated pelvic floor hypertonicity with either global tenderness or myofascial trigger points, and 92% displayed evidence of impaired muscular relaxation, hallmarks of myofascial dysfunction. To confirm this symptom pattern was attributable to the pelvic floor musculature, we confirmed the presence of "persistency" in 68 patients with pelvic floor myofascial dysfunction established through comprehensive examination and electromyography and corroborated by improvement with pelvic floor myofascial release. These symptoms distinguish subjects with myofascial dysfunction from subjects with OAB, IC/BPS, and asymptomatic controls, confirming MUFS is a distinct LUTS symptom complex.

Indexed as

Lower Urinary Tract SymptomsPelvic FloorHumansMuscle HypertoniaTrigger Points

Identifiers

PMID37891217
PMCPMC10611808
OpenAlexW4387975152

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.