ArticleNature communications2023
Neuronal connected burst cascades bridge macroscale adaptive signatures across arousal states.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- Article
- The Protonic Brain: Nanoscale pH Dynamics, Proton Wires, and Acid-Base Information Coding in Neural Tissue.International journal of molecular sciences · 2026Review
- Computational Pipeline to Infer Micro-, Meso-, and Macro-Scale Brain-State Transitions.Methods in molecular biology (Clifton, N.J.) · 2026Article
- A hierarchy of time constants and reliable signal propagation in the marmoset cerebral cortex.Nature communications · 2025Article
- Review
- Magnetoencephalography Dimensionality Reduction Informed by Dynamic Brain States.The European journal of neuroscience · 2025Article
- A burst-dependent thalamocortical substrate for perceptual awareness.PLoS computational biology · 2025Article
- Context-Sensitive Conscious Interpretation and Layer-5 Pyramidal Neurons in Multistable Perception.Brain and behavior · 2025Review
- Neuromorphic algorithms for brain implants: a review.Frontiers in neuroscience · 2025Review
- EEG spectral attractors identify a geometric core of brain dynamics.Patterns (New York, N.Y.) · 2024Article
- Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human brain displays a rich repertoire of states that emerge from the microscopic interactions of cortical and subcortical neurons. Difficulties inherent within large-scale simultaneous neuronal recording limit our ability to link biophysical processes at the microscale to emergent macroscopic brain states. Here we introduce a microscale biophysical network model of layer-5 pyramidal neurons that display graded coarse-sampled dynamics matching those observed in macroscale electrophysiological recordings from macaques and humans. We invert our model to identify the neuronal spike and burst dynamics that differentiate unconscious, dreaming, and awake arousal states and provide insights into their functional signatures. We further show that neuromodulatory arousal can mediate different modes of neuronal dynamics around a low-dimensional energy landscape, which in turn changes the response of the model to external stimuli. Our results highlight the promise of multiscale modelling to bridge theories of consciousness across spatiotemporal scales.
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Registered trials
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