ArticleGenes & development2023
A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels.
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Article in Genes & development, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Pooled it
- Rett syndrome: MECP2 biology, multisystem pathophysiology, and the evolving therapeutic landscape.European journal of pediatrics · 2026Review
- Single-nucleus profiling reveals a core disease signature and cell type-specific vulnerabilities in early Rett syndrome.Science advances · 2026Article
- MECP2 mutations disrupt pluripotent stem cell fate through remodeling of the three-dimensional genome.Cell death & disease · 2026Article
- Modulating alternative splicing ofScience translational medicine · 2026Article
- Distinct SOX9 single-molecule dynamics characterize adult differentiation and fetal-like reprogrammed states in intestinal organoids.Stem cell reports · 2026Article
- C/EBP-β/MeCP2/Wnt Axis Participates in the Testicular Injury in Rats Under Simulated Microgravity Conditions.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Exploring the complexity of MECP2 function in Rett syndrome.Nature reviews. Neuroscience · 2025Review
- Article
- Advances of deep Neural Networks (DNNs) in the development of peptide drugs.Future medicinal chemistry · 2025Review
- Comparative epigenetics of domestic animals: focusing on DNA accessibility and its impact on gene regulation and traits.Journal of veterinary science · 2025Review
- Interaction of methyl-CpG-binding protein 2 (MeCP2) with distinct enhancers in the mouse cortex.Nature neuroscience · 2025Article
- Epigenetic Regulation and Neurodevelopmental Disorders: From MeCP2 to the TCF20/PHF14 Complex.Genes · 2024Review
- Testing the PEST hypothesis using relevant Rett mutations in MeCP2 E1 and E2 isoforms.Human molecular genetics · 2024Article
- Epigenetic modulators provide a path to understanding disease and therapeutic opportunity.Genes & development · 2024Review
- Imaging the binding of MECP2 to DNA.Genes & development · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 3 institutions in 2 countries.
Jian Zhou *Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.ORCID 0000-0001-8045-0578
Claudia Cattoglio *Department of Molecular and Cell Biology, Li Ka Shing Center for Biomedical and Health Sciences, California Institute for Regenerative Medicine (CIRM) Center of Excellence, University of California, Berkeley, Berkeley, California 94720, USA.ORCID 0000-0001-6100-0491
Yingyao Shao *Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Harini P TirumalaDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.ORCID 0000-0002-1318-2072
Carlo VetrallaDepartment of Molecular and Cell Biology, Li Ka Shing Center for Biomedical and Health Sciences, California Institute for Regenerative Medicine (CIRM) Center of Excellence, University of California, Berkeley, Berkeley, California 94720, USA.
Sameer S BajikarDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.ORCID 0000-0002-8868-881X
Yan LiDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Hu ChenJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030, USA.
Qi WangJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030, USA.
Zhenyu WuJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030, USA.
Bing TangJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030, USA.
Mahla ZahabiyonDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Aleksandar BajicDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.ORCID 0000-0002-1255-9835
Xiangling MengJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030, USA.
Jack J FerrieDepartment of Molecular and Cell Biology, Li Ka Shing Center for Biomedical and Health Sciences, California Institute for Regenerative Medicine (CIRM) Center of Excellence, University of California, Berkeley, Berkeley, California 94720, USA.
Anel LaGroneAdvanced Technology Cores, Baylor College of Medicine, Houston, Texas 77030, USA.ORCID 0000-0002-9664-7663
Ping ZhangDepartment of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA.
Jean J KimAdvanced Technology Cores, Baylor College of Medicine, Houston, Texas 77030, USA.
Jianrong TangJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030, USA.ORCID 0000-0001-5664-2692
Zhandong LiuJan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030, USA.
Xavier DarzacqDepartment of Molecular and Cell Biology, Li Ka Shing Center for Biomedical and Health Sciences, California Institute for Regenerative Medicine (CIRM) Center of Excellence, University of California, Berkeley, Berkeley, California 94720, USA.ORCID 0000-0003-2537-8395
Nathaniel HeintzLaboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10065, USA.
Robert TjianDepartment of Molecular and Cell Biology, Li Ka Shing Center for Biomedical and Health Sciences, California Institute for Regenerative Medicine (CIRM) Center of Excellence, University of California, Berkeley, Berkeley, California 94720, USA.ORCID 0000-0003-0539-8217
Huda Y ZoghbiDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA; hzoghbi@bcm.edu jmlim@berkeley.edu.ORCID 0000-0002-0700-3349
Baylor College of Medicine · USHoward Hughes Medical Institute · USCalifornia Institute for Regenerative Medicine · US
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9MPreclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9MMOLECULAR PATHOGENESIS STUDIES OF RETT SYNDROMER01NS057819 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI ZOGHBI, HUDA Y · 2006 to 2025
$7.5MStudying the effects and mechanisms of deep brain stimulation in Rett syndrome miceR01NS100738 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI Jianrong Tang · 2018 to 2026
$3.3MDeep brain stimulation in Rett syndrome mice: cognitive benefits and their mechanismsR56NS100738 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI TANG, JIANRONG · 2017 to 2017
$338kInvestigating the role of Growth-differentiation factor 11 in neurodevelopmental and MECP2-related disordersF32HD100048 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI BAJIKAR, SAMEER · 2019 to 2021
$168kThe role of Tcf20 in activity-dependent inhibitory signaling and autism spectrum disorder pathogenesisK99NS129963 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI ZHOU, JIAN · 2023 to 2023
$122kNanoCellect WOLF Cell Sorter and N1 Single-Cell Dispenser SystemS10OD028591 · OD · BAYLOR COLLEGE OF MEDICINE · PI KIM, JEAN J · 2020 to 2020
$108kHoward Hughes Medical InstituteNCI NIH HHS P30 CA125123NICHD NIH HHS F32 HD100048NICHD NIH HHS P50 HD103555NIH HHS S10 OD028591NINDS NIH HHS K99 NS129963NINDS NIH HHS R01 NS057819NINDS NIH HHS R01 NS100738NINDS NIH HHS R56 NS100738
Abstract
Loss-of-function mutations in
Indexed as
ChromatinRett SyndromeAnimalsBrainFemaleHumansMaleMethyl-CpG-Binding Protein 2MiceMutationNeuronsChromatinMethyl-CpG-Binding Protein 2chromatin dynamicsMeCP2neurological disordersRett syndromesingle-molecular imaging
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.