Evidence map›Paper›PMID 37890895›Full record

ArticleBMJ open ophthalmology2023

Association of macular pigment optical density with retinal layer thicknesses in eyes with and without manifest primary open-angle glaucoma.

Thomas Lawler, J A Mares, Zhe Liu, Catherine Thuruthumaly, Tyler Etheridge, Thasarat S Vajaranant, Amitha Domalpally, Billy R Hammond, Robert B Wallace, Lesley F Tinker and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Thomas LawlerDepartment of Nutritional Sciences, College of Agricultural & Life Sciences, University of Wisconsin, Madison, Wisconsin, USA.
J A MaresDepartment of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA.
Zhe LiuDepartment of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA.
Catherine ThuruthumalyOphthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Tyler EtheridgeDepartment of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA.
Thasarat S VajaranantDepartment of Ophthalmology & Visual Sciences, University of Illinois, Chicago, Illinois, USA.
Amitha DomalpallyDepartment of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA.
Billy R HammondDepartment of Psychology, University of Georgia, Athens, Georgia, USA.
Robert B WallaceDepartment of Epidemiology, University of Iowa, Iowa City, Iowa, USA.
Lesley F TinkerDepartment of Cancer Prevention, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Marine NalbandyanDepartment of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA.ORCID 0000-0003-0604-5333
Barbara E K KleinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA.
Yao LiuDepartment of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA yao.liu2@wisc.edu.ORCID 0000-0002-0700-0148
Carotenoids in Age-Related Eye Disease Study Investigators
Second Carotenoids in Age-Related Eye Disease Study Research Group
University of Wisconsin–Madison · USFred Hutch Cancer Center · USMedical College of Wisconsin · USUniversity of Georgia · USUniversity of Illinois Urbana-Champaign · USUniversity of Iowa · US

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
UW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI Donna M Peters · 2005 to 2026
$12.6M
TRAINING IN NUTRITIONT32DK007665 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI GUY E GROBLEWSKI, Chi- Liang Eric Yen · 1993 to 2026
$9.2M
Macular Pigment in Aging and DiseaseR01EY025292 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI BLODI, BARBARA A, MARES, JULIE A · 2015 to 2019
$4.5M
CAROTENOIDS &AGE-RELATED EYE DISEASE IN WOMEN'S HEALTHU10EY013018 · NEI · UNIVERSITY OF WISCONSIN MADISON · PI MARES, JULIE A · 2000 to 2004
$4.4M
Diet and Lifestyle Factors Reducing Risk for Age-Related Eye DiseaseR01EY016886 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI IYENGAR, SUDHA K, MARES, JULIE A · 2007 to 2013
$2.7M
NCATS NIH HHS UL1 TR002373NEI NIH HHS P30 EY016665NEI NIH HHS R01 EY016886NEI NIH HHS R01 EY025292NEI NIH HHS U10 EY013018NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNIDDK NIH HHS T32 DK007665
6 · The paper itself

Abstract

objectiveTo investigate associations between baseline macular pigment optical density (MPOD) and retinal layer thicknesses in eyes with and without manifest primary open-angle glaucoma (POAG) in the Carotenoids in Age-Related Eye Disease Study 2 (CAREDS2). METHODS AND ANALYSIS: MPOD was measured at CAREDS baseline (2001-2004) via heterochromatic flicker photometry (0.5° from foveal centre). Peripapillary retinal nerve fibre layer (RNFL), macular ganglion cell complex (GCC), ganglion cell layer (GCL), inner plexiform layer (IPL), and RNFL thicknesses were measured at CAREDS2 (2016-2019) via spectral-domain optical coherence tomography. Associations between MPOD and retinal thickness were assessed using multivariable linear regression.

resultsAmong 742 eyes (379 participants), manifest POAG was identified in 50 eyes (32 participants). In eyes without manifest POAG, MPOD was positively associated with macular GCC, GCL and IPL thicknesses in the central subfield (P-trend ≤0.01), but not the inner or outer subfields. Among eyes with manifest POAG, MPOD was positively associated with macular GCC, GCL, IPL and RNFL in the central subfield (P-trend ≤0.03), but not the inner or outer subfields, and was positively associated with peripapillary RNFL thickness in the superior and temporal quadrants (P-trend≤0.006).

conclusionWe observed a positive association between MPOD and central subfield GCC thickness 15 years later. MPOD was positively associated with peripapillary RNFL superior and temporal quadrant thicknesses among eyes with manifest POAG. Our results linking low MPOD to retinal layers that are structural indicators of early glaucoma provide further evidence that carotenoids may be protective against manifest POAG.

Indexed as

Glaucoma, Open-AngleMacula LuteaMacular PigmentHumansIntraocular PressureRetinal Ganglion CellsTomography, Optical CoherenceMacular Pigmentepidemiologyglaucomaimagingoptic nerveretina

Identifiers

PMID37890895
PMCPMC10619120
OpenAlexW4387996774

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.