Evidence map›Paper›PMID 37890672›Full record

SynthesisThe American journal of clinical nutrition2024

Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis.

Nagendra K Monangi, Huan Xu, Yue-Mei Fan, Rasheeda Khanam, Waqasuddin Khan, Saikat Deb, Jesmin Pervin, Joan T Price, Lovejeet Kaur, INTERBIO-21st Study Consortium and 64 more

Open access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The American journal of clinical nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

74 authors at 20 institutions in 15 countries.

Nagendra K MonangiDivision of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States; Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center and March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, Ohio, United States; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States. Electronic address: nagendra.monangi@cchmc.org.
Huan XuCenter for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center and March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, Ohio, United States; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Yue-Mei FanCenter for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. Electronic address: yuemei.fan@tuni.fi.
Rasheeda KhanamInternational Center for Maternal and Newborn Health, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States.
Waqasuddin KhanBiorepository and Omics Research Group, Department of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, Aga Khan University, Karachi, Sindh, Pakistan.
Saikat DebResearch Division, Public Health Laboratory, Center for Public Health Kinetics, Chake Chake, Tanzania.
Jesmin PervinMaternal and Child Health Division, International Centre for Diarrheal Disease Research, Bangladesh, Dhaka District, Bangladesh.
Joan T PriceObstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Lovejeet KaurChild and Maternal Health Program, Translational Health Science and Technology Institute (THSTI), Faridabad, India.
INTERBIO-21st Study Consortium
Abdullah Al MahmudNutrition and Clinical Services Division, International Centre for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh.
Le Quang ThanhTu Du Hospital, Ho Chi Ming City, Vietnam.
Angharad CareDepartment of Women's and Children's Health, The University of Liverpool, Liverpool, United Kingdom.
Julio A LanderoDepartment of Chemistry, University of Cincinnati, Cincinnati, OH, United States.
Gerald F CombsJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States.
Elizabeth BellingDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Joanne ChappellDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Jing ChenDivision of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. Electronic address: jing.chen2@cchmc.org.
Fansheng KongDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Craig LacherUSDA-ARS, Grand Forks Human Nutrition Research Center, Grand Forks, ND, United States.
Salahuddin AhmedProjahnmo Research Foundation, Dhaka, Bangladesh.
Nabidul Haque ChowdhuryProjahnmo Research Foundation, Dhaka, Bangladesh.
Sayedur RahmanProjahnmo Research Foundation, Dhaka, Bangladesh.
Furqan KabirBiorepository and Omics Research Group, Department of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, Aga Khan University, Karachi, Sindh, Pakistan.
Imran NisarBiorepository and Omics Research Group, Department of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, Aga Khan University, Karachi, Sindh, Pakistan.
Aneeta HotwaniBiorepository and Omics Research Group, Department of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, Aga Khan University, Karachi, Sindh, Pakistan.
Usma MehmoodBiorepository and Omics Research Group, Department of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, Aga Khan University, Karachi, Sindh, Pakistan.
Ambreen NizarBiorepository and Omics Research Group, Department of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, Aga Khan University, Karachi, Sindh, Pakistan.
Javairia KhalidBiorepository and Omics Research Group, Department of Pediatrics and Child Health, Faculty of Health Sciences, Medical College, Aga Khan University, Karachi, Sindh, Pakistan.
Usha DhingraCenter for Public Health Kinetics, New Delhi, India.
Arup DuttaCenter for Public Health Kinetics, New Delhi, India.
Said Mohamed AliResearch Division, Public Health Laboratory, Center for Public Health Kinetics, Chake Chake, Tanzania.
Fahad AftabResearch Division, Public Health Laboratory, Center for Public Health Kinetics, Chake Chake, Tanzania.
Mohammed Hamad JumaResearch Division, Public Health Laboratory, Center for Public Health Kinetics, Chake Chake, Tanzania.
Monjur RahmanNutrition and Clinical Services Division, International Centre for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh.
Tahmeed AhmedNutrition and Clinical Services Division, International Centre for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh.
M Munirul IslamNutrition and Clinical Services Division, International Centre for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh.
Bellington VwalikaSchool of Medicine, University of Zambia, Lusaka, Zambia.
Patrick MusondaSchool of Public Health, University of Zambia, Lusaka, Zambia.
Ulla AshornCenter for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Kenneth MaletaSchool of Public Health and Family Medicine, University of Malawi College of Medicine, Blantyre, Malawi.
Mikko HallmanSchool of Public Health and Family Medicine, University of Malawi College of Medicine, Blantyre, Malawi; Medical Research Centre Oulu, PEDEGO Research Unit, University of Oulu, Oulu, Pohjois-Pohjanmaa, Finland.
Laura GoodfellowDepartment of Women's and Children's Health, The University of Liverpool, Liverpool, United Kingdom.
Juhi K GuptaDepartment of Women's and Children's Health, The University of Liverpool, Liverpool, United Kingdom.
Ana AlfirevicDepartment of Women's and Children's Health, The University of Liverpool, Liverpool, United Kingdom.
Susan K MurphyDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, United States.
Larry RandDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco School of Medicine, San Francisco, CA, United States.
Kelli K RyckmanDepartment of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, United States.
Jeffrey C MurrayDepartment of Pediatrics, University of Iowa, Iowa City, IA, United States.
Rajiv BahlDepartment of Maternal, Newborn, Child and Adolescent Health, World Health Organization, Geneva, Switzerland.
James A LitchGlobal Alliance to Prevent Prematurity and Stillbirth, Lynnwood, WA, United States.
Courtney Baruch-GravettGlobal Alliance to Prevent Prematurity and Stillbirth, Lynnwood, WA, United States.
Shailaja SoporyChild and Maternal Health Program, Translational Health Science and Technology Institute (THSTI), Faridabad, India.
Uma Chandra Mouli NatchuSt. John's Research Institute (SJRI), Bangladore, India.
Pavitra V KumarGeochronology Group, Inter University Accelerator Centre (IUAC), Delhi, India.
Neha KumariChild and Maternal Health Program, Translational Health Science and Technology Institute (THSTI), Faridabad, India.
Ramachandran ThiruvengadamChild and Maternal Health Program, Translational Health Science and Technology Institute (THSTI), Faridabad, India.
Atul Kumar SinghGeochronology Group, Inter University Accelerator Centre (IUAC), Delhi, India.
Pankaj KumarGeochronology Group, Inter University Accelerator Centre (IUAC), Delhi, India.
GARBH-Ini study teamChild and Maternal Health Program, Translational Health Science and Technology Institute (THSTI), Faridabad, India.
Zarko AlfirevicDepartment of Women's and Children's Health, The University of Liverpool, Liverpool, United Kingdom.
Abdullah H BaquiInternational Center for Maternal and Newborn Health, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States.
Shinjini BhatnagarChild and Maternal Health Program, Translational Health Science and Technology Institute (THSTI), Faridabad, India.
Jane E HirstTu Du Hospital, Ho Chi Ming City, Vietnam; Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, United Kingdom.
Cathrine HoyoDepartment of Biological Sciences and Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina, United States.
Fyezah JehanDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Laura Jelliffe-PawlowskiDepartment of Epidemiology and Biostatistics, University of California San Francisco School of Medicine, San Francisco, CA, United States.
Anisur RahmanMaternal and Child Health Division, International Centre for Diarrheal Disease Research, Bangladesh, Dhaka District, Bangladesh.
Daniel E RothCentre for Global Child Health, Hospital for Sick Children, University of Toronto, Toronto, Canada; Department of Pediatrics, University of Toronto, Toronto, Canada.
Sunil SazawalResearch Division, Public Health Laboratory, Center for Public Health Kinetics, Chake Chake, Tanzania; Center for Public Health Kinetics, New Delhi, India.
Jeffrey S A StringerObstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Per AshornCenter for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Department of Pediatrics, Tampere University Hospital, Tampere, Finland.
Ge ZhangCenter for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center and March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, Ohio, United States; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States. Electronic address: ge.zhang@cchmc.org.
Louis J MugliaCenter for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center and March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, Ohio, United States; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States; Burroughs Wellcome Fund, Research Triangle Park, NC, United States.
Cincinnati Children's Hospital Medical Center · USAga Khan University · PKInternational Centre for Diarrhoeal Disease Research · BDPublic Health Laboratory Ivo de Carneri · TZUniversity of Liverpool · GBUniversity of Oxford · GBBiomedical Research Foundation · BDJohns Hopkins University · USUniversity of Zambia · ZMAga Khan University Nairobi · KEKenya Medical Research Institute · KETampere University · FITranslational Health Science and Technology Institute · INUniversity of California, San Francisco · USUniversity of Iowa · USUniversity of Malawi · MWUniversity of North Carolina at Chapel Hill · USDuke Medical Center · USGrand Forks Human Nutrition Research Center · USLiverpool School of Tropical Medicine · GB

Funding

Duke University Program in Environmental HealthT32ES021432 · NIEHS · DUKE UNIVERSITY · PI Akhenaton-Andrew Dhafir Jones, Joel Newman Meyer · 2013 to 2026
$4.0M
Follow-up and Maintenance of the Newborn Epigenetics STudy (NEST) CohortR24ES028531 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI HOYO, CATHRINE, MURPHY, SUSAN KAY · 2018 to 2022
$1.9M
Medical Research Council MR/T040750/1NIEHS NIH HHS R24 ES028531NIEHS NIH HHS T32 ES021432World Health Organization 001
6 · The paper itself

Abstract

backgroundCopper (Cu), an essential trace mineral regulating multiple actions of inflammation and oxidative stress, has been implicated in risk for preterm birth (PTB).

objectivesThis study aimed to determine the association of maternal Cu concentration during pregnancy with PTB risk and gestational duration in a large multicohort study including diverse populations.

methodsMaternal plasma or serum samples of 10,449 singleton live births were obtained from 18 geographically diverse study cohorts. Maternal Cu concentrations were determined using inductively coupled plasma mass spectrometry. The associations of maternal Cu with PTB and gestational duration were analyzed using logistic and linear regressions for each cohort. The estimates were then combined using meta-analysis. Associations between maternal Cu and acute-phase reactants (APRs) and infection status were analyzed in 1239 samples from the Malawi cohort.

resultsThe maternal prenatal Cu concentration in our study samples followed normal distribution with mean of 1.92 μg/mL and standard deviation of 0.43 μg/mL, and Cu concentrations increased with gestational age up to 20 wk. The random-effect meta-analysis across 18 cohorts revealed that 1 μg/mL increase in maternal Cu concentration was associated with higher risk of PTB with odds ratio of 1.30 (95% confidence interval [CI]: 1.08, 1.57) and shorter gestational duration of 1.64 d (95% CI: 0.56, 2.73). In the Malawi cohort, higher maternal Cu concentration, concentrations of multiple APRs, and infections (malaria and HIV) were correlated and associated with greater risk of PTB and shorter gestational duration.

conclusionsOur study supports robust negative association between maternal Cu and gestational duration and positive association with risk for PTB. Cu concentration was strongly correlated with APRs and infection status suggesting its potential role in inflammation, a pathway implicated in the mechanisms of PTB. Therefore, maternal Cu could be used as potential marker of integrated inflammatory pathways during pregnancy and risk for PTB.

Indexed as

Premature BirthCopperFemaleGestational AgeHumansInfant, NewbornInflammationLive BirthPregnancyRisk FactorsCopperacute-phase reactantscoppergestational durationinflammationlow- and middle-income countriesnutritionpregnancypreterm birth

Identifiers

PMID37890672
PMCPMC10808817
OpenAlexW4387953020

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.