ArticleJournal of vascular surgery. Venous and lymphatic disorders2024
Intralesional injection of bleomycin in the management of low flow vascular malformations: Results and factors affecting the outcome.
Article in Journal of vascular surgery. Venous and lymphatic disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Bleomycin ElectroScleroTherapy (BEST): mechanistic parallels to electrochemotherapy, experimental models, and unresolved questions.Radiology and oncology · 2026Review
- Case Report: Clinical management of genital, perineal, and perianal venous malformation in a five-year-old boy: therapeutic decision-making and review of current literature.Frontiers in pediatrics · 2026Article
- The Role of Bleomycin Sclerotherapy in Venous Malformation Management: A Narrative Review.Life (Basel, Switzerland) · 2025Review
- Safety and Clinical Outcome of Bleomycin-Electrosclerotherapy (BEST) Treating Lymphatic Malformations (LMs).Cardiovascular and interventional radiology · 2025Article
- Predictive Factors for Response to Percutaneous Bleomycin in Lymphatic-Venous Malformations of the Head and Neck.Journal of clinical medicine · 2025Article
- Application of Radiofrequency Ablation for the Treatment of Cutaneous Hemangioma and Vascular Malformation in a Cockscomb Model.Dermatology research and practice · 2025Article
- Efficacy of sclerotherapy with pingyangmycin and polidocanol for venous malformations.Frontiers in surgery · 2025Article
- Multi-disciplinary diagnosis and management of verrucous venous malformation of the right knee: a case report.Frontiers in radiology · 2025Article
- CT-guided percutaneous aspiration and bleomycin sclerotherapy for symptomatic hepatic cysts: technique and three-year outcomes.Frontiers in medicine · 2025Article
- Vascular malformations in the thighs of identical twin sisters.Journal of vascular surgery. Venous and lymphatic disorders · 2024Article
- Microneedle delivery system with rapid dissolution and sustained release of bleomycin for the treatment of hemangiomas.Journal of nanobiotechnology · 2024Article
- Slow-Flow Venous Malformation of Vulva in a Pre-menarcheal Girl.Indian dermatology online journalArticle
- Intralesional Bleomycin in the Management of Low-flow Vascular Malformations - A Case Report.Annals of maxillofacial surgeryArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEthanol has been a commonly used sclerosant for low-flow vascular malformations, but it carries a high risk of complications. Bleomycin has been recently introduced as a potentially effective treatment. The aim of this study was to evaluate the safety and efficacy of bleomycin intralesional injection for the treatment of low-flow vascular malformations and determine the different factors affecting the outcome. PATIENTS AND
methodsA total of fifty patients with low-flow vascular malformations were enrolled in the study between April 2020 and March 2022. All patients underwent preoperative duplex ultrasound and magnetic resonance angiography. The procedure was performed under ultrasound and fluoroscopic guidance. All patients were assessed for the objective improvement, ultrasound assessment, and patient-reported outcome.
resultsThe overall rate of objective improvement was 79.53% (78.05% in venous and 87.5% in lymphatic malformations), whereas 81.25% of the patients showed a degree of size reduction or complete obliteration on postoperative ultrasound. The patient-reported outcome analysis showed a statistically significant improvement in the mean score for the pain, overall symptoms, and self-confidence. On regression analysis, the only factor associated with poor objective outcome was diffuse lesions (ill-defined or extending in more than one body region or one compartment). No major complications were recorded.
conclusionsBleomycin intralesional injection is a safe and effective treatment for low-flow vascular malformations.
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