ArticleThe Journal of clinical endocrinology and metabolism2024
High Incidence of Diabetes Mellitus After Distal Pancreatectomy and Its Predictors: A Long-term Follow-up Study.
Article in The Journal of clinical endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07665710 (Prediction of Pancreatogenic Diabetes After Partial Resection of the Pancreas), which is not on this map. Cited by 12 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prediction of Pancreatogenic Diabetes After Partial Resection of the Pancreas
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Research trends and knowledge structure of pancreatic cancer and type 2 diabetes mellitus research: a two-decade CiteSpace analysis.Frontiers in endocrinology · 2026Pooled it
- New-Onset Diabetes Mellitus Following Pancreatic Injury: A Systematic Review.World journal of surgery · 2025Pooled it
- Functional Advantage of Central Pancreatectomy Over Distal Pancreatectomy for Benign or Low-Grade Malignant Tumors: A Comparative Analysis Based on 75-g Oral Glucose Tolerance Test.Annals of gastroenterological surgery · 2026Article
- Laparoscopic enucleation vs. pancreatectomy for small pancreatic neuroendocrine neoplasms: long-term functional and oncological outcomes.Surgical endoscopy · 2025Article
- Efficacy and safety of lateral approach laparoscopic spleen-preserving distal pancreatectomy: a multicenter retrospective cohort study.Scientific reports · 2025Article
- Significance of Pancreatic Steatosis as a Predictor of New-Onset Diabetes Mellitus Following Pancreatectomy.Pancreas · 2025Article
- Glucose metabolism after distal pancreatectomy - deterioration of beta cell function becomes noticeable at an early stage: a retrospective cohort study.BMC surgery · 2025Article
- Review
- Difference in fecal and oral microbiota between pancreatic cancer and benign/low-grade malignant tumor patients.BMC microbiology · 2024Article
- Genetics of type-1 diabetes.Diabetology international · 2024Review
- High Incidence of Diabetes Mellitus After Distal Pancreatectomy and Its Predictors: A Long-term Follow-up Study.The Journal of clinical endocrinology and metabolism · 2024Article
- Machine learning-based prediction of long-term new-onset diabetes mellitus risk after pancreaticoduodenectomy using radiomics.Digital healthArticle
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
contextGlucose tolerance worsens after distal pancreatectomy (DP); however, the long-term incidence and factors affecting interindividual variation in this worsening are unclear.
objectiveTo investigate the changes in diabetes-related traits before and after DP and to clarify the incidence of diabetes and its predictors.
methodsAmong 493 registered patients, 117 underwent DP. Among these, 56 patients without diabetes before surgery were included in the study. Glucose and endocrine function were prospectively assessed using a 75-g oral glucose tolerance test preoperatively, 1 month after DP, and every 6 months thereafter for up to 36 months. Pancreatic volumetry was performed using multidetector row computed tomography before and after surgery.
resultsInsulin secretion decreased and blood glucose levels worsened after DP. Residual pancreatic volume was significantly associated with the reserve capacity of insulin secretion but not with blood glucose levels or the development of diabetes. Among 56 patients, 33 developed diabetes mellitus. The cumulative incidence of diabetes at 36 months after DP was 74.1%. Multivariate Cox regression analysis showed that impaired glucose tolerance as a preoperative factor as well as a decreased insulinogenic index and impaired glucose tolerance at 1 month postoperatively were identified as risk factors for diabetes following DP.
conclusionImpaired glucose tolerance and reduced early-phase insulin response to glucose are involved in the development of new-onset diabetes after DP; the latter is an additional factor in the development of diabetes and becomes apparent when pancreatic beta cell mass is reduced after DP.
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