Evidence map›Paper›PMID 37889748›Full record

ArticleCell reports2023

Pain and itch coding mechanisms of polymodal sensory neurons.

Changxiong Guo, Haowu Jiang, Cheng-Chiu Huang, Fengxian Li, William Olson, Weishan Yang, Michael Fleming, Guang Yu, George Hoekel, Wenqin Luo and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

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  8. MDFIC2 is a PIEZO channel modulator that can alleviate mechanical allodynia associated with neuropathic pain.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Changxiong GuoWashington University Pain Center, Department of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.
Haowu JiangWashington University Pain Center, Department of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.
Cheng-Chiu HuangWashington University Pain Center, Department of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.
Fengxian LiWashington University Pain Center, Department of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.
William OlsonDepartment of Neuroscience, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA.
Weishan YangWashington University Pain Center, Department of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.
Michael FlemingDepartment of Neuroscience, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA.
Guang YuWashington University Pain Center, Department of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.
George HoekelWashington University Pain Center, Department of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.
Wenqin LuoDepartment of Neuroscience, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA.
Qin LiuWashington University Pain Center, Department of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA. Electronic address: qinliu@wustl.edu.
Washington University in St. Louis · USUniversity of Pennsylvania · US

Funding

The Neural Basis of Ocular SensationsR01EY024704 · NEI · WASHINGTON UNIVERSITY · PI LIU, QIN · 2014 to 2024
$4.3M
Molecular mechanisms in controlling development of touch-sensing neuronsR01NS083702 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI LUO, WENQIN · 2013 to 2022
$4.1M
The Neural Mechanism of Respiratory Allergies and InfectionsR01AI163146 · NIAID · WASHINGTON UNIVERSITY · PI LIU, QIN · 2021 to 2025
$2.6M
Determine Functions of the Lateral Habenular and Trigeminal High Threshold Mechanoreceptors in Mediating Scratching-induced ResponsesR01NS131209 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Wenqin Luo · 2023 to 2026
$2.1M
HISTAMINE-INDEPENDENT MAST CELL NERVE INTERACTIONS IN ALLERGYR01AI125743 · NIAID · WASHINGTON UNIVERSITY · PI LIU, QIN · 2016 to 2020
$1.9M
NEI NIH HHS R01 EY024704NIAID NIH HHS R01 AI125743NIAID NIH HHS R01 AI163146NINDS NIH HHS R01 NS083702NINDS NIH HHS R01 NS131209
6 · The paper itself

Abstract

Pain and itch coding mechanisms in polymodal sensory neurons remain elusive. MrgprD

Indexed as

PruritusSensory Receptor CellsGlutamatesHumansPainSignal TransductionGlutamatesCP: NeuroscienceglutamateitchMrgprDneural codingneuromedin Bneurotransmitterspainpolymodal sensory neurons

Identifiers

PMID37889748
PMCPMC10729537
OpenAlexW4387996928

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.