Evidence map›Paper›PMID 37889667›Full record

ArticleAnimals : an open access journal from MDPI2023

Is Oral Vaccination against

Guillermo Ramis, Francisco Murciano, Juan Orengo, Belén González-Guijarro, Amanda Cuellar-Flores, Daniel Serrano, Antonio Muñoz Luna, Pedro Sánchez-Uribe, Laura Martínez-Alarcón

Open access · goldAbstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Guillermo RamisDepartamento de Producción Animal, Facultad de Veterinaria, Universidad de Murcia, 30100 Murcia, Spain.ORCID 0000-0001-5580-1612
Francisco MurcianoDepartamento de Producción Animal, Facultad de Veterinaria, Universidad de Murcia, 30100 Murcia, Spain.ORCID 0009-0008-6973-3436
Juan OrengoDepartamento de Producción Animal, Facultad de Veterinaria, Universidad de Murcia, 30100 Murcia, Spain.ORCID 0000-0001-8399-9865
Belén González-GuijarroDepartamento de Producción Animal, Facultad de Veterinaria, Universidad de Murcia, 30100 Murcia, Spain.
Amanda Cuellar-FloresDepartamento de Producción Animal, Facultad de Veterinaria, Universidad de Murcia, 30100 Murcia, Spain.
Daniel SerranoDepartamento de Sanidad Animal, Facultad de Veterinaria, Universidad de Murcia, 30100 Murcia, Spain.
Antonio Muñoz LunaDepartamento de Producción Animal, Facultad de Veterinaria, Universidad de Murcia, 30100 Murcia, Spain.
Pedro Sánchez-UribeELANCO Animal Health, 28108 Alcobendas, Spain.
Laura Martínez-AlarcónInstituto Murciano de Investigación en Biomédicina (IMIB), 30120 Murcia, Spain.ORCID 0000-0001-7497-6709
Universidad de Murcia · ESInstituto Murciano de Investigación Biosanitaria · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough zinc oxide has been banned at therapeutic doses in the EU, its use is still legal in most countries with industrial pig farming. This compound has been shown to be very effective in preventing

methodsA group of piglets were orally vaccinated at weaning and divided into two subgroups; one group was fed a feed containing 2500 ppm zinc oxide (V + ZnO) for the first 15 days post-vaccination (dpv) and the other was not (V). Faeces were sampled from the animals at 6, 8, 11, 13, and 15 dpv. Unvaccinated animals without ZnO in their feed (Neg) were sampled simultaneously and, on day 15 post-vaccination, were also compared with a group of unvaccinated animals with ZnO in their feed (ZnO).

resultsDifferences were found in

conclusionsAlthough some differences in the excretion of the vaccine strain were found when comparing both vaccinated groups, there are no remarkable differences in immune stimulation or soluble IgA production when comparing animals orally vaccinated against

Indexed as

Escherichia colioral vaccinationzinc oxide

Identifiers

PMID37889667
PMCPMC10252008
OpenAlexW4378471153

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.