ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2024
Temporal Dynamics of Epigenetic Aging and Frailty From Midlife to Old Age.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Applying the Bradford Hill Criteria to Assess the Independent Causal Roles of Aging and Medication in Frailty Progression: A Systematic Review.Drugs & aging · 2026Pooled it
- From Athletic Performance to Functional Ageing: Shared Genetic Architecture, Redox-Inflammatory Pathways and Functional Reserve Across the Life Course-A Narrative Review.Biomedicines · 2026Review
- Association between pace of aging estimated from blood DNA methylation and all-cause mortality: the HUNT study.Clinical epigenetics · 2026Article
- From the lab to lifestyle: epigenetic clocks in personalized aging and health.Biogerontology · 2026Review
- Pilot study of epigenetic aging and treatment response to semaglutide in the SLIM LIVER study.npj aging · 2026Article
- Article
- Epigenetic aging markers in the association between frailty and mortality among U.S. adults.BMC medicine · 2026Article
- Longitudinal changes in epigenetic clocks predict survival in the InCHIANTI cohort.Nature aging · 2026Article
- Epidemiological approaches to refine biomarkers of aging.Nature aging · 2026Article
- Article
- Falls in demented patients are associated with reduced EEG functional connectivity of the dorsal attention network.Clinical neurophysiology practice · 2026Article
- DNA methylation signatures of frailty beyond age: a longitudinal study of female and male mice.bioRxiv : the preprint server for biology · 2025Article
- The contribution of depression and anxiety to frailty in men and women: data from a longitudinal population-based cohort study.BMC geriatrics · 2025Article
- Epigenetic Aging and Treatment Response to Semaglutide in the SLIM LIVER Study.Research square · 2025Article
- Article
- Functional Foods in Modern Nutrition Science: Mechanisms, Evidence, and Public Health Implications.Nutrients · 2025Review
- Epigenetic Biomarkers of Cardiovascular Risk in Frail Patients-A Scope Review.Current issues in molecular biology · 2025Review
- Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice.npj aging · 2025Article
- Marital and living status and biological ageing trajectories: a longitudinal cohort study with a 20-year follow-up.Biogerontology · 2025Article
- Accelerated biological aging and midlife frailty among U.S. military veterans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Observational
Corrections and comments
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8 authors.
Funding
Abstract
backgroundDNA methylation-derived epigenetic clocks and frailty are well-established biological age measures capturing different aging processes. However, whether they are dynamically linked to each other across chronological age remains poorly understood.
methodsThis analysis included 1 309 repeated measurements in 524 individuals aged 50-90 years from the Swedish Adoption/Twin Study of Aging. Frailty was measured using a validated 42-item frailty index (FI). Five epigenetic clocks were calculated, including 4 principal component (PC)-based clocks trained on chronological age (PCHorvathAge and PCHannumAge) and aging-related physiological conditions (PCPhenoAge and PCGrimAge), and a pace of aging clock (DunedinPACE). Using dual change score models, we examined the dynamic, bidirectional associations between each of the epigenetic clocks and the FI over age to test for potential causal associations.
resultsThe FI exhibited a nonlinear, accelerated increase across the older adulthood, whereas the epigenetic clocks mostly increased linearly with age. For PCHorvathAge, PCHannumAge, PCPhenoAge, and PCGrimAge, their associations with the FI were primarily due to correlated levels at age 50 but with no evidence of a dynamic longitudinal association. In contrast, we observed a unidirectional association between DunedinPACE and the FI, where a higher DunedinPACE predicted a subsequent increase in the FI, but not vice versa.
conclusionsOur results highlight a temporal order between epigenetic aging and frailty such that changes in DunedinPACE precede changes in the FI. This potentially suggests that the pace of aging clock can be used as an early marker of the overall physiological decline at system level.
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