Evidence map›Paper›PMID 37889436›Full record

ArticleJournal of epidemiology and global health2023

A Population-Based Outcome-Wide Association Study of the Comorbidities and Sequelae Following COVID-19 Infection.

Yuyang Zhang, Junhong Li, Lan Feng, Yaxin Luo, Wendu Pang, Ke Qiu, Minzi Mao, Yao Song, Danni Cheng, Yufang Rao and 11 more

Abstract read
In one paragraph

Article in Journal of epidemiology and global health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Yuyang Zhang *Department of Otolaryngology-Head & Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.
Junhong Li *Department of Otolaryngology-Head & Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.
Lan Feng *Department of Otolaryngology-Head & Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.
Yaxin LuoMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Wendu PangDepartment of Otolaryngology-Head & Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.
Ke QiuDepartment of Otolaryngology-Head & Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.
Minzi MaoDepartment of Otolaryngology-Head & Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.
Yao SongDepartment of Otolaryngology-Head & Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.
Danni ChengDepartment of Otolaryngology-Head & Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.
Yufang RaoDepartment of Otolaryngology-Head & Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.
Xinyi WangDepartment of Otolaryngology-Head & Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.
Yao HuWest China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China.
Zhiye YingWest China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China.
Xiaobin PuDepartment of Oto-Rhino-Laryngology, Langzhong People's Hospital, Langzhong, China.
Shuyan LinDepartment of Otolaryngology-Head & Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.
Shaohui HuangDepartment of Radiation Oncology, Princess Margaret Cancer Centre and University of Toronto, Toronto, Canada.
Geoffrey LiuDivision of Medical Oncology and Hematology, Department of Medicine, Princess Margaret Cancer Center, University Health Network, University of Toronto, Toronto, Canada.
Wei ZhangWest China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China.
Wei XuDepartment of Biostatistics, Princess Margaret Cancer Centre and Dalla Lana School of Public Health, 10-511, 610 University Avenue Toronto, Toronto, ON, Canada. Wei.Xu@uhnresearch.ca.
Yu ZhaoDepartment of Otolaryngology-Head & Neck Surgery, West China Hospital, Sichuan University, Chengdu, China. yuzhao@wchscu.edu.cn.
Jianjun RenDepartment of Otolaryngology-Head & Neck Surgery, West China Hospital, Sichuan University, Chengdu, China. Jianjun.Ren@scu.edu.cn.ORCID 0000-0002-5938-688X

Funding

West China Hospital, Sichuan University 2019HXFH003West China Hospital, Sichuan University ZYJC21027
6 · The paper itself

Abstract

backgroundImmense attention has been given to the outcome of COVID-19 infection. However, comprehensive studies based on large populational cohort with long-term follow-up are still lacking. This study aimed to investigate the risk of various short-term comorbidities (within one month) and long-term sequelae (above one month) after COVID-19 infection.

methodsIn this large prospective cohort study with 14 months follow-up information based on UK biobank, we included 16,776 COVID-19-positive participants and 58,281 COVID-19-negative participants matched for comparison. The risk of each comorbidity and sequela was evaluated by multivariable logistic regression analysis and presented as hazard ratio (HR) and 95% confidence interval (95% CI).

resultsCOVID-19-positive individuals had a higher risk of 47 types of comorbidities within one month following COVID-19 infection, especially those who were older, male, overweight/obese, ever-smoked, with more pre-existing comorbidities and hospitalized. About 70.37% of COVID-19 patients with comorbidities had more than one co-occurring comorbidities. Additionally, only 6 high-risk sequelae were observed after one month of COVID-19 infection, and the incidence was relatively low (< 1%).

conclusionIn addition to long-term sequelae following COVID-19 infection, plenty of comorbidities were observed, especially in patients with older age, male gender, overweight/obese, more pre-existing comorbidities and severe COVID-19, indicating that more attention should be given to these susceptible persons within this period.

Indexed as

COVID-19ComorbidityDisease ProgressionHumansMaleObesityOverweightProspective StudiesSARS-CoV-2ComorbidityCOVID-19IncidenceLong-term sequelaeOutcome-wide association study

Identifiers

PMID37889436
PMCPMC10686900

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.