ReviewSkeletal radiology2024
Revision of the 1994 World Health Organization T-score definition of osteoporosis for use in older East Asian women and men to reconcile it with their lifetime risk of fragility fracture.
Review in Skeletal radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- The observation that older men suffer from hip fracture at DXA T-scores higher than older women and a proposal of a new low BMD category, osteofrailia, for predicting fracture risk in older men.Skeletal radiology · 2025Pooled it
- Diagnostic performance of the vertebral bone quality score for osteoporosis is minimally influenced by lipid parameters in lumbar fusion patients: a retrospective study.Asian spine journal · 2026Article
- Lumbar spine DXA T-score and QCT BMD cutpoint values for defining osteofrailia among older men: a framework for further refinement.Skeletal radiology · 2026Review
- Relevance of vertebral fractural deformity for hip fracture prediction: a community-based study of older Chinese women and men.Skeletal radiology · 2026Article
- Time to reframe osteoporosis: a position statement to characterize the osteoporosis care gap.JBMR plus · 2026Review
- Considerations on the lumbar spine bone mineral density cutpoint values for defining osteofrailia among older Chinese men.Quantitative imaging in medicine and surgery · 2025Article
- The diagnostic cutoff value of vertebral bone quality score for osteoporosis is significantly influenced by the magnetic field in patients undergoing lumbar surgery.Quantitative imaging in medicine and surgery · 2025Article
- Prediction of postoperative proximal junctional kyphosis/failure in adult degenerative scoliosis via magnetic resonance imaging-based vertebral bone quality, computed tomography-based Hounsfield units, and sagittal vertical axis.Quantitative imaging in medicine and surgery · 2025Article
- Estimation of T scores with Hologic using NatIve vs. Caucasian data in IndiAns (ETHNICA): a single center retrospective study.BMC musculoskeletal disorders · 2025Article
- Correlation analysis of lumbar disc degeneration characteristics and bone mineral density in patients with osteoporosis based on the Roussouly classification.Quantitative imaging in medicine and surgery · 2025Article
- Quantitative CT lumbar spine BMD cutpoint value for classifying osteoporosis among older Chinese men can be the same as that of older Chinese women, both much lower than the value for Caucasians.Skeletal radiology · 2025Review
- Lower osteoporotic-like vertebral fractural deformity (OLVF) prevalence and severity among older Thais and Indonesians than among older Chinese.Quantitative imaging in medicine and surgery · 2025Article
- Majority of hip fragility fractures among older people can be predicted by a DXA examination: an updated analysis of literature results and empirical Chinese data with a focus on the validation of the newly proposed osteofrailia criterion for men.Quantitative imaging in medicine and surgery · 2025Article
- Bone Density Screening Rates Among Medicare Beneficiaries: An Analysis with a focus on Asian Americans.Skeletal radiology · 2024Article
- Diagnostic value of a magnetic resonance imaging (MRI)-based vertebral bone quality score for bone mineral density assessment: an updated systematic review and meta-analysis.Quantitative imaging in medicine and surgery · 2024Article
- Fewer spine degenerations among Southeast Asians than among Southern Chinese suggests populations from a warmer climate have inherently better spine health.Quantitative imaging in medicine and surgery · 2024Article
- Quantitative CT lumbar spine BMD cutpoint value for classifying osteoporosis among older East Asian women should be lower than the value for Caucasians.Skeletal radiology · 2024Article
- Ultrashort echo time MRI detects significantly lower collagen but higher pore water in the tibial cortex of female patients with osteopenia and osteoporosis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- For older women, the majority of hip fragility fractures and radiographic vertebral fragility fractures occur among the densitometrically osteoporotic population: a literature analysis.Quantitative imaging in medicine and surgery · 2024Review
- More evidence to support a lower quantitative computed tomography (QCT) lumbar spine bone mineral density (BMD) cutpoint value for classifying osteoporosis among older East Asian women than for Caucasians.Quantitative imaging in medicine and surgery · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 8 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The 1994 WHO criterion of a T-score ≤ -2.5 for densitometric osteoporosis was chosen because it results in a prevalence commensurate with the observed lifetime risk of fragility fractures in Caucasian women aged ≥ 50 years. Due to the much lower risk of fragility fracture among East Asians, the application of the conventional WHO criterion to East Asians leads to an over inflated prevalence of osteoporosis, particularly for spine osteoporosis. According to statistical modeling and when a local BMD reference is used, we tentatively recommend the cutpoint values for T-score of femoral neck, total hip, and spine to be approximately -2.7, -2.6, and -3.7 for Hong Kong Chinese women. Using radiographic osteoporotic vertebral fracture as a surrogate clinical endpoint, we empirically demonstrated that a femoral neck T-score of -2.77 for Chinese women was equivalent to -2.60 for Italian women, a spine T-score of -3.75 for Chinese women was equivalent to -2.44 for Italian women, and for Chinese men a femoral neck T-score of -2.77 corresponded to spine T-score of -3.37. For older Chinese men, we tentatively recommend the cutpoint values for T-score of femoral neck, total hip, and spine to be approximately -2.7, -2.6, and -3.2. With the BMD reference published by IKi et al. applied, T-score of femoral neck, total hip, and spine of -2.75, -3.0, and -3.9 for Japanese women will be more in line with the WHO osteoporosis definition. The revised definition of osteoporosis cutpoint T-scores for East Asians will allow a more meaningful international comparison of disease burden.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.