ArticleSleep2024
Comprehensive assessment of sleep duration, insomnia, and brain structure within the UK Biobank cohort.
Article in Sleep, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Default mode network and visual network responsiveness to transcutaneous auricular vagus nerve stimulation predict its variable efficacy in primary insomnia disorder.Frontiers in neurology · 2025Trial
- Poor sleep is robustly correlated with accelerated aging but the evidence for causation is mixed.medRxiv : the preprint server for health sciences · 2026Article
- Development and validation of a Cog-Free risk predicting tool for dementia in a community setting.General psychiatry · 2026Article
- Associations of sleep behaviors with white matter hyperintensity volume in middle-aged to older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Exposome-wide patterns predict brain health in aging.Nature communications · 2026Article
- Cortical morphology of insomnia with objective short sleep duration phenotype.Sleep & breathing = Schlaf & Atmung · 2026Article
- Multimodal MRI radiomics and deep learning for brain age prediction: age-corrected brain age gap analysis in patients with insomnia.Biomedical engineering online · 2026Article
- Can we predict sleep health based on brain features? A large-scale machine learning study using the UK Biobank.Brain communications · 2026Article
- Demyelination and Cognitive Performance in Long COVID Patients with Insomnia and/or Depression.International journal of molecular sciences · 2025Article
- Brain Age Acceleration on MRI Due to Poor Sleep: Associations, Mechanisms, and Clinical Implications.Brain sciences · 2025Review
- Sleep Health and White Matter Integrity in the UK Biobank.Journal of sleep research · 2025Article
- A [Journal of neuroinflammation · 2025Article
- Associations of Chronic Insomnia, Longitudinal Cognitive Outcomes, Amyloid-PET, and White Matter Changes in Cognitively Normal Older Adults.Neurology · 2025Article
- Associations of adherence to a healthy sleep pattern with the dementia risk in the UK biobank.Alzheimer's research & therapy · 2025Article
- Healthy Lifestyle, Metabolic Signature, and Risk of Cardiovascular Diseases: A Population-Based Study.Nutrients · 2024Article
- Poor sleep and decreased cortical thickness in veterans with mild traumatic brain injury and post-traumatic stress disorder.Military Medical Research · 2024Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
STUDY
objectivesTo assess for associations between sleeping more than or less than recommended by the National Sleep Foundation (NSF), and self-reported insomnia, with brain structure.
methodsData from the UK Biobank cohort were analyzed (N between 9K and 32K, dependent on availability, aged 44 to 82 years). Sleep measures included self-reported adherence to NSF guidelines on sleep duration (sleeping between 7 and 9 hours per night), and self-reported difficulty falling or staying asleep (insomnia). Brain structural measures included global and regional cortical or subcortical morphometry (thickness, surface area, volume), global and tract-related white matter microstructure, brain age gap (difference between chronological age and age estimated from brain scan), and total volume of white matter lesions.
resultsLonger-than-recommended sleep duration was associated with lower overall grey and white matter volumes, lower global and regional cortical thickness and volume measures, higher brain age gap, higher volume of white matter lesions, higher mean diffusivity globally and in thalamic and association fibers, and lower volume of the hippocampus. Shorter-than-recommended sleep duration was related to higher global and cerebellar white matter volumes, lower global and regional cortical surface areas, and lower fractional anisotropy in projection fibers. Self-reported insomnia was associated with higher global gray and white matter volumes, and with higher volumes of the amygdala, hippocampus, and putamen.
conclusionsSleeping longer than recommended by the NSF is associated with a wide range of differences in brain structure, potentially indicative of poorer brain health. Sleeping less than recommended is distinctly associated with lower cortical surface areas. Future studies should assess the potential mechanisms of these differences and investigate long sleep duration as a putative marker of brain health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.