ReviewJournal of the American Heart Association2023
Obstructive Hypertrophic Cardiomyopathy and Takotsubo Syndrome: How to Deal With Left Ventricular Ballooning?
Review in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Mechanistic Underpinnings of Mitral Regurgitation in Patients With Takotsubo Syndrome.JACC. Advances · 2026Article
- Ventricular-Arterial Coupling in Takotsubo Syndrome: Controversies and Opportunities.Journal of cardiovascular development and disease · 2026Article
- Takotsubo syndrome in the setting of cardiac pacing: A review of mechanistic and clinical perspectives.Heart failure reviews · 2026Review
- Syncope in a Patient with Takotsubo Syndrome: Additional Issues to Consider.Clinical practice and cases in emergency medicine · 2026Article
- Severe pulmonary disease as a driver of dynamic left ventricular outflow tract obstruction in stress cardiomyopathy.Respiratory medicine case reports · 2026Article
- Letter to the editor concerning: Catastrophic apical ballooning in obstructive hypertrophic cardiomyopathy patient treated with mavacamten.European heart journal. Case reports · 2026Article
- Takotsubo Syndrome and Cancer: Pathophysiological Links and Clinical Perspectives.Biomedicines · 2025Review
- Not Just Another Broken Heart: A Case Report of Takotsubo Cardiomyopathy Causing Syncope.Clinical practice and cases in emergency medicine · 2025Article
- Sigmoid Septum: A Bystander or Contributor to a Left Ventricular Outflow Tract Obstruction in Takotsubo Syndrome - A Case Report with a Literature Review.Internal medicine (Tokyo, Japan) · 2025Review
- Beyond hypertrophic cardiomyopathy: unmasking alternative causes of LVOT obstruction on CMR.The international journal of cardiovascular imaging · 2025Article
- Article
- Tailored Therapies for Cardiogenic Shock in Hypertrophic Cardiomyopathy: Navigating Emerging Strategies.Journal of cardiovascular development and disease · 2024Review
- Takotsubo Syndrome: An International Expert Consensus Report on Practical Challenges and Specific Conditions (Part-2: Specific Entities, Risk Stratification and Challenges After Recovery)Balkan medical journal · 2024Article
- Takotsubo Syndrome: An International Expert Consensus Report on Practical Challenges and Specific Conditions (Part-1: Diagnostic and Therapeutic Challenges)Balkan medical journal · 2024Article
- A case report of severe left ventricular outflow tract obstruction in a middle-aged adult with chest pain and shock.Heliyon · 2024Article
- Incidence of Takotsubo cardiomyopathy in patients with acute coronary syndrome: a single center retrospective analysis.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2024Article
- Risk of stress cardiomyopathy associated with selective serotonin reuptake inhibitors and serotonin and norepinephrine reuptake inhibitors: a real-world pharmacovigilance analysis.Scientific reports · 2024Article
- Dynamic LVOT Obstruction as a Cause of Hemodynamic Instability in Takotsubo Syndrome.Journal of investigative medicine high impact case reportsArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Currently, there are 2 proposed causes of acute left ventricular ballooning. The first is the most cited hypothesis that ballooning is caused by direct catecholamine toxicity on cardiomyocytes or by microvascular ischemia. We refer to this pathogenesis as Takotsubo syndrome. More recently, a second cause has emerged: that in some patients with underlying hypertrophic cardiomyopathy, left ventricular ballooning is caused by the sudden onset of latent left ventricular outflow tract obstruction. When it becomes severe and unrelenting, severe afterload mismatch and acute supply-demand ischemia appear and result in ballooning. In the context of 2 causes, presentations might overlap and cause confusion. Knowing the pathophysiology of each mechanism and how to determine a correct diagnosis might guide treatment.
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