Evidence map›Paper›PMID 37889088›Full record

ArticleMolecular pharmaceutics2023

Freeze-Induced Phase Transition and Local Pressure in a Phospholipid/Water System: Novel Insights Were Obtained from a Time/Temperature Resolved Synchrotron X-ray Diffraction Study.

Miguel A Rodrigues, Olga Matsarskaia, Pedro Rego, Vitor Geraldes, Lauren E Connor, Iain D H Oswald, Michael Sztucki, Evgenyi Shalaev

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 70% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Miguel A RodriguesCentro de Química Estrutural, Instituto Superior Tecnico, University of Lisbon, Lisbon 1049-001, Portugal.
Olga MatsarskaiaInstitut Laue-Langevin, 71 Avenue des Martyrs, Grenoble 38000, France.ORCID 0000-0002-7293-7287
Pedro RegoCentro de Química Estrutural, Instituto Superior Tecnico, University of Lisbon, Lisbon 1049-001, Portugal.
Vitor GeraldesCentro de Química Estrutural, Instituto Superior Tecnico, University of Lisbon, Lisbon 1049-001, Portugal.
Lauren E ConnorStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, U.K.
Iain D H OswaldStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, U.K.ORCID 0000-0003-4339-9392
Michael SztuckiEuropean Synchrotron Radiation Facility, Grenoble Cedex 9 38043, France.ORCID 0000-0002-5314-9402
Evgenyi ShalaevAbbvie Inc., 2525 Dupont Drive, Irvine, California 92612, United States.ORCID 0000-0002-8611-0627
University of Lisbon · PTUniversity of Strathclyde · GBAbbVie (United States) · USEuropean Synchrotron Radiation Facility · FRInstitut Laue-Langevin · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Water-to-ice transformation results in a 10% increase in volume, which can have a significant impact on biopharmaceuticals during freeze-thaw cycles due to the mechanical stresses imparted by the growing ice crystals. Whether these stresses would contribute to the destabilization of biopharmaceuticals depends on both the magnitude of the stress and sensitivity of a particular system to pressure and sheer stresses. To address the gap of the "magnitude" question, a phospholipid, 1,2-dipalmitoyl-

Indexed as

Biological ProductsWater1,2-DipalmitoylphosphatidylcholineCalorimetry, Differential ScanningFreezingIcePhase TransitionPhospholipidsSynchrotronsTemperatureX-Ray Diffraction1,2-DipalmitoylphosphatidylcholineBiological ProductsIcePhospholipidsWaterfreeze-induced pressurefreezingicephospholipidssmall-angle X-ray scatteringsynchrotron X-ray

Identifiers

PMID37889088
PMCPMC10630958
OpenAlexW4387965596

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.