ArticleUlusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES2023
The effect of Dermalix® on colon anastomosis leakage: experimental study.
Article in Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Dermalix enhances angiogenesis and collagen remodeling in an ischemic colon anastomosis rat model.Acta cirurgica brasileira · 2026Article
- The effect of Tannic acid on colonic anastomosis in abdominal sepsis: An experimental study.PloS one · 2025Article
- The effect of pembrolizumab on the healing of colonic anastomosis: a pre-clinical study in Wistar rats.Annals of gastroenterologyArticle
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2 authors.
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Abstract
backgroundThis study aimed to evaluate the effect of Dermalix® (Dx) on wound healing and anastomotic leakage in a rat model of end-to-end colon anastomosis.
methodsThe study was carried out on 40 rats, as divided into three groups, including a negative control group (n=10, laparotomy only) control group (n=15, colon anastomosis), and the experimental group (n=15, colon anastomosis plus Dx applied to anastomo-sis site). The rats were sacrificed on the 3rd post-operative day, and resected colon segments were evaluated for bursting pressure (mmHg) using an infusion pump set-up and for pathological parameters of wound healing including neutrophil infiltration, epithelial regeneration, granulation tissue formation, local inflammatory response, neovascularization, and foreign body reaction.
resultsAnastomotic leakage rate was significantly lower (1 rat vs. 6 rats, P=0.040). Moreover, mean bursting pressure was signifi-cantly (2.95 times) higher (mean 121 vs. 41 mmHg, respectively, P<0.05) in the Dx experimental group than in the control group. Dx was considered to significantly accelerate wound healing by increasing neovascularization (P<0.001). Control and experimental groups were similar in terms of other pathological parameters.
conclusionBased on significantly lower rate of anastomotic leakage and its positive effects especially on the bursting pressure and neovascularization, Dx seems to be considered as a promising technology in preventing anastomotic leakage.
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