Evidence map›Paper›PMID 37888906›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2024

Paradoxical Modulation of STN β-Band Activity with Medication Compared to Deep Brain Stimulation.

Meghan E Hill, Luke A Johnson, Jing Wang, David Escobar Sanabria, Rémi Patriat, Scott E Cooper, Michael C Park, Noam Harel, Jerrold L Vitek, Joshua E Aman

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Meghan E HillDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0001-9019-1186
Luke A JohnsonDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-9069-1436
Jing WangDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.
David Escobar SanabriaDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.
Rémi PatriatDepartment of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.
Scott E CooperDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.
Michael C ParkDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.
Noam HarelDepartment of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.
Jerrold L VitekDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.
Joshua E AmanDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.
University of Minnesota · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
TRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Mehmet Akcakaya · 2019 to 2026
$11.7M
Understanding Circuit Dynamics in Parkinson's Disease using Real-Time Neural ControlP50NS123109 · NINDS · UNIVERSITY OF MINNESOTA · PI AMAN, JOSHUA E · 2021 to 2025
$11.3M
Pathophysiology-based approaches to deep brain stimulation for Parkinson's diseaseP50NS098573 · NINDS · UNIVERSITY OF MINNESOTA · PI VITEK, JERROLD L · 2016 to 2020
$9.1M
Institutional Center Cores for Advanced NeuroimagingP30NS076408 · NINDS · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2020
$4.2M
Computer Aided Diagnostic System for Prostate Cancer Detection Using Quantitative Multiparametric MRIR01CA241159 · NCI · UNIVERSITY OF MINNESOTA · PI METZGER, GREGORY JOHN · 2021 to 2025
$3.0M
NCATS NIH HHS UL1 TR002494NCI NIH HHS R01 CA241159NIBIB NIH HHS P41 EB027061NINDS NIH HHS P30 NS076408NINDS NIH HHS P50 NS098573NINDS NIH HHS P50 NS123109
6 · The paper itself

Abstract

backgroundExcessive subthalamic nucleus (STN) β-band (13-35 Hz) synchronized oscillations has garnered interest as a biomarker for characterizing disease state and developing adaptive stimulation systems for Parkinson's disease (PD).

objectivesTo report on a patient with abnormal treatment-responsive modulation in the β-band.

methodsWe examined STN local field potentials from an externalized deep brain stimulation (DBS) lead while assessing PD motor signs in four conditions (OFF, MEDS, DBS, and MEDS+DBS).

resultsThe patient presented here exhibited a paradoxical increase in β power following administration of levodopa and pramipexole (MEDS), but an attenuation in β power during DBS and MEDS+DBS despite clinical improvement of 50% or greater under all three therapeutic conditions.

conclusionsThis case highlights the need for further study on the role of β oscillations in the pathophysiology of PD and the importance of personalized approaches to the development of β or other biomarker-based DBS closed loop algorithms. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Indexed as

Deep Brain StimulationParkinson DiseaseSubthalamic NucleusBiomarkersHumansLevodopaBiomarkersLevodopadeep brain stimulationlevodopalocal field potentialsParkinson's diseaseβ-band activity

Identifiers

PMID37888906
PMCPMC10843006
OpenAlexW4387966407

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.