Evidence map›Paper›PMID 37888625›Full record

ArticleToxins2023

Transcriptome Analysis of Deoxynivalenol (DON)-Induced Hepatic and Intestinal Toxicity in Zebrafish: Insights into Gene Expression and Potential Detoxification Pathways.

Feng Yao, Miaomiao Zhao, Yaowen Du, Guoli Chang, Chuanpeng Li, Ruiyu Zhu, Chenggang Cai, Suqing Shao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Feng YaoCollege of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China.
Miaomiao ZhaoCollege of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China.
Yaowen DuCollege of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China.
Guoli ChangCollege of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China.
Chuanpeng LiCollege of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China.
Ruiyu ZhuCollege of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China.
Chenggang CaiCollege of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China.ORCID 0000-0002-9519-9803
Suqing ShaoGuelph Research and Development Centre, Agriculture and Agri-Food Canada, Guelph, ON N1G 5C9, Canada.
Zhejiang University of Science and Technology · CNAgriculture and Agri-Food Canada · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effects of deoxynivalenol (DON, 50 µg/mL) on the zebrafish liver and intestine were studied. Differentially expressed genes (DEGs) from mRNA and lncRNA were analyzed by RNA seq. Gene Ontology (GO) and signaling pathways were studied where the top 30 DEGs of each type of RNA were involved. The results showed there were 2325 up-regulated and 934 down-regulated DEGs of lncRNA in the intestinal tract, and 95 up-regulated genes and 211 down-regulated genes in the liver, respectively. GO functional annotation analysis showed that lncRNA was enriched in the biological processes, involving the RNA splicing, CSF1-CSF1R complexes, and MAP kinase activity. DEGs of lncRNA located in the KEGG signal pathways include the C-type lectin receptor signaling and the NOD-like receptor signaling pathways. Metabolism involves the biosynthesis of indole alkaloids, cancer pathways for human disease, MAPK and Rap1signaling pathways for environmental information processing, necroptosis and focal adhesion for cell processes. The mRNA gene expression analysis showed there were 1939 up-regulated, 1172 down-regulated genes and 866 up-regulated, 1211 down-regulated genes in the intestine and liver of zebrafish, respectively. This study provides transcriptome analysis and toxicological investigation of DON in the zebrafish liver and intestine, offering insights into gene expression patterns and potential detoxification pathways.

Indexed as

RNA, Long NoncodingZebrafishAnimalsGene ExpressionGene Expression ProfilingHumansIntestinesLiverRNA, MessengerTranscriptomeTrichothecenesdeoxynivalenolRNA, Long NoncodingRNA, MessengerTrichothecenesDONintestinal toxicityliver toxicitytranscriptomezebrafish

Identifiers

PMID37888625
PMCPMC10611307
OpenAlexW4387264505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.